RGS12

RGS12
Identifiers
Aliases	RGS12, regulator of G protein signaling 12
External IDs	OMIM: 602512; MGI: 1918979; HomoloGene: 2195; GeneCards: RGS12; OMA:RGS12 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EBZ, 2KV8
Gene location (Human)
Chr.	Chromosome 4 (human)
End	3,439,913 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	35,196,988 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; mucosa of esophagus; ; skin of leg; ; right uterine tube; ; skin of abdomen; ; right frontal lobe; ; right hemisphere of cerebellum; ; prefrontal cortex; ; ectocervix;
	Top expressed in
	spermatocyte; ; lip; ; hand; ; ventricular zone; ; genital tubercle; ; Rostral migratory stream; ; spermatid; ; ganglionic eminence; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase regulator activity; GTPase activator activity; GTPase activity;
Cellular component	cytoplasm; cell projection; nuclear matrix; synapse; condensed nuclear chromosome; cell junction; dendrite; plasma membrane; nucleus; nucleolus; cytosol;
Biological process	regulation of G protein-coupled receptor signaling pathway; transcription, DNA-templated; positive regulation of GTPase activity; negative regulation of signal transduction; signal transduction; regulation of catalytic activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6002
	71729
	ENSG00000159788
	ENSMUSG00000029101
	O14924
	Q8CGE9
NM_002926; NM_198227; NM_198229; NM_198230; NM_198430;
	NM_198432; NM_198587; NM_001394154; NM_001394155; NM_001394156; NM_001394157; NM_001394158; NM_001394159; NM_001394161; NM_001394162; NM_001394163
	NM_001163512; NM_173402
	NP_002917; NP_937870; NP_937872
NP_001156984; NP_775578; NP_001390400; NP_001390401; NP_001390402;
	NP_001390403; NP_001390404; NP_001390405; NP_001390406; NP_001390407
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.^[5]^[6]

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.^[6]

Interactions

RGS12 has been shown to interact with GNAI1,^[7] GNAI3,^[7] and the kappa opioid receptor.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000159788 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029101 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, et al. (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". The Journal of Biological Chemistry. 273 (28): 17749–17755. doi:10.1074/jbc.273.28.17749. PMID 9651375.
1 2 "Entrez Gene: RGS12 regulator of G-protein signalling 12".
1 2 Kimple RJ, De VL, Tronchère H, Behe CI, Morris RA, Gist FM, et al. (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry. 276 (31): 29275–29281. doi:10.1074/jbc.M103208200. PMID 11387333.
↑ Gross JD, Kaski SW, Schmidt KT, Cogan ES, Boyt KM, Wix K, et al. (September 2019). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. PMC 6785087. PMID 31141817.

Frohme M, Scharm B, Delius H, Knecht R, Hoheisel JD (June 2000). "Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue". Annals of the New York Academy of Sciences. 910 (1): 85–104, discussion 104–5. Bibcode:2000NYASA.910...85F. doi:10.1111/j.1749-6632.2000.tb06703.x. PMID 10911908. S2CID 25399395.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Snow BE, Antonio L, Suggs S, Gutstein HB, Siderovski DP (April 1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14". Biochemical and Biophysical Research Communications. 233 (3): 770–777. doi:10.1006/bbrc.1997.6537. PMID 9168931.
Chatterjee TK, Fisher RA (2000). "Novel alternative splicing and nuclear localization of human RGS12 gene products". The Journal of Biological Chemistry. 275 (38): 29660–29671. doi:10.1074/jbc.M000330200. PMID 10869340.
Schiff ML, Siderovski DP, Jordan JD, Brothers G, Snow B, De Vries L, et al. (December 2000). "Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel". Nature. 408 (6813): 723–727. doi:10.1038/35047093. PMID 11130074. S2CID 205011654.
Snow BE, Brothers GM, Siderovski DP (2002). "Molecular Cloning of Regulators of G-Protein Signaling Family Members and Characterization of Binding Specificity of RGS 12 PDZ Domain". G Protein Pathways, Part B: G Proteins and their Regulators. Methods in Enzymology. Vol. 344. pp. 740–761. doi:10.1016/S0076-6879(02)44752-0. ISBN 978-0-12-182245-3. PMID 11771424.
Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, et al. (February 2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–185. doi:10.1006/geno.2002.6693. PMID 11829488. S2CID 16065132.
Chatterjee TK, Fisher RA (2002). "RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression". Molecular and Cellular Biology. 22 (12): 4334–4345. doi:10.1128/MCB.22.12.4334-4345.2002. PMC 133853. PMID 12024043.
Potocnik U, Glavac D, Ravnik-Glavac M (2003). "Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability". Genes, Chromosomes & Cancer. 36 (1): 48–56. doi:10.1002/gcc.10141. PMID 12461749. S2CID 30132562.

\* Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–1450. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.

Yang S, Li YP (2007). "RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro". Journal of Bone and Mineral Research. 22 (1): 45–54. doi:10.1359/jbmr.061007. PMC 3559086. PMID 17042716.
Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V (February 2018). "Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants". Journal of Psychopharmacology. 32 (2). Oxford, England: 191–203. doi:10.1177/0269881117742100. PMC 5942192. PMID 29364035.
Schroer AB, Mohamed JS, Willard MD, Setola V, Oestreich E, Siderovski DP (2019). "A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation". PLOS ONE. 14 (8) e0216167. Bibcode:2019PLoSO..1416167S. doi:10.1371/journal.pone.0216167. PMC 6691989. PMID 31408461.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000159788 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029101 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9651375-5] Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, et al. (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". The Journal of Biological Chemistry. 273 (28): 17749–17755. doi:10.1074/jbc.273.28.17749. PMID 9651375.

[entrez-6] 1 2 "Entrez Gene: RGS12 regulator of G-protein signalling 12".

[pmid11387333-7] 1 2 Kimple RJ, De VL, Tronchère H, Behe CI, Morris RA, Gist FM, et al. (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry. 276 (31): 29275–29281. doi:10.1074/jbc.M103208200. PMID 11387333.

[8] Gross JD, Kaski SW, Schmidt KT, Cogan ES, Boyt KM, Wix K, et al. (September 2019). "Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior". Neuropsychopharmacology. 44 (10): 1728–1741. doi:10.1038/s41386-019-0423-7. PMC 6785087. PMID 31141817.

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RGS12

Interactions

References

Further reading