REG4

REG4
Identifiers
Aliases	REG4, GISP, REG-IV, RELP, regenerating family member 4
External IDs	OMIM: 609846; MGI: 1914959; HomoloGene: 41671; GeneCards: REG4; OMA:REG4 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KV3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	119,811,580 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	98,144,064 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; duodenum; ; jejunal mucosa; ; body of pancreas; ; mucosa of sigmoid colon; ; rectum; ; pancreatic ductal cell; ; appendix; ; testicle; ; mucosa of transverse colon;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; left colon; ; Paneth cell; ; duodenum; ; ileum; ; jejunum; ; intestinal villus; ; epithelium of small intestine; ; migratory enteric neural crest cell; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; heparin binding; mannan binding; carbohydrate binding; transmembrane signaling receptor activity;
Cellular component	cytoplasm; extracellular region;
Biological process	response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	83998
	67709
	ENSG00000134193
	ENSMUSG00000027876
	Q9BYZ8
	Q9D8G5
	NM_032044; NM_001159352; NM_001159353
	NM_026328
	NP_001152824; NP_001152825; NP_114433
	NP_080604
	Wikidata
View/Edit Human	View/Edit Mouse

Regenerating islet-derived protein 4 (REG4) is a protein that in humans (Homo sapiens) is encoded by the REG4 gene.^[5]^[6]^[7] REG4 is located on Chromosome 1 in humans and is expressed in the proximal gastrointestinal (GI) tract.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134193 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027876 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK (Apr 2001). "Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV". Biochim Biophys Acta. 1518 (3): 287–93. doi:10.1016/s0167-4781(00)00284-0. PMID 11311942.
↑ Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T (Nov 2002). "Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas". Int J Cancer. 103 (2): 185–93. doi:10.1002/ijc.10788. PMID 12455032.
↑ "Entrez Gene: REG4 regenerating islet-derived family, member 4".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kämäräinen M, Heiskala K, Knuutila S, et al. (2003). "RELP, a Novel Human Reg-Like Protein with Up-Regulated Expression in Inflammatory and Metaplastic Gastrointestinal Mucosa". Am. J. Pathol. 163 (1): 11–20. doi:10.1016/S0002-9440(10)63625-5. PMC 1868159. PMID 12819006.
Zhang Y, Lai M, Lv B, et al. (2003). "Overexpression of Reg IV in colorectal adenoma". Cancer Lett. 200 (1): 69–76. doi:10.1016/S0304-3835(03)00460-9. PMID 14550954.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gu Z, Rubin MA, Yang Y, et al. (2005). "Reg IV: a promising marker of hormone refractory metastatic prostate cancer". Clin. Cancer Res. 11 (6): 2237–43. doi:10.1158/1078-0432.CCR-04-0356. PMID 15788672.
Bishnupuri KS, Luo Q, Murmu N, et al. (2006). "Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas". Gastroenterology. 130 (1): 137–49. doi:10.1053/j.gastro.2005.10.001. PMID 16401477.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Takehara A, Eguchi H, Ohigashi H, et al. (2006). "Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4". Cancer Sci. 97 (11): 1191–7. doi:10.1111/j.1349-7006.2006.00297.x. PMC 11159249. PMID 16918991.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134193 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027876 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11311942-5] 1 2 Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK (Apr 2001). "Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV". Biochim Biophys Acta. 1518 (3): 287–93. doi:10.1016/s0167-4781(00)00284-0. PMID 11311942.

[pmid12455032-6] Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T (Nov 2002). "Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas". Int J Cancer. 103 (2): 185–93. doi:10.1002/ijc.10788. PMID 12455032.

[entrez-7] "Entrez Gene: REG4 regenerating islet-derived family, member 4".

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REG4

References

Further reading