RBPJL

RBPJL
Identifiers
Aliases	RBPJL, RBPSUHL, SUHL, RBPL, recombination signal binding protein for immunoglobulin kappa J region like
External IDs	OMIM: 616104; MGI: 1196616; GeneCards: RBPJL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F8X, 3NBN, 3V79
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.12 Start 45,306,840 bp End 45,317,824 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H3|2 85.16 cM Start 164,245,061 bp End 164,257,368 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas testicle gonad body of stomach fundus islet of Langerhans right lobe of liver duodenum cervix bone marrow cell Top expressed in male urethra pancreas left lung lobe right lung stomach entorhinal cortex Ileal epithelium right lung lobe islet of Langerhans morula More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific sequence-specific DNA binding Cellular component nucleus transcription regulator complex Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated signal transduction positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 11317 19668 Ensembl ENSG00000124232 ENSMUSG00000017007 UniProt Q9UBG7 O08674 RefSeq (mRNA) NM_001281448 NM_001281449 NM_014276 NM_009036 RefSeq (protein) NP_001268377 NP_001268378 NP_055091 NP_033062 Location (UCSC) Chr 20: 45.31 – 45.32 Mb Chr 2: 164.25 – 164.26 Mb PubMed search
Wikidata
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Recombining binding protein suppressor of hairless-like protein is a protein that in humans is encoded by the RBPJL gene. This protein is highly expressed in the pancreas (especially acinar cells), and is involved in its development.

In research in mice, similar to its paralog, RBPJ, RBPJL forms a complex with PTF1A. Early on, RBPJ is the main protein of the two involved in the PTF1A complex, which preserves the progenitor state of the cells of the pancreas. However, as the pancreas gradually develops, RBPJL replaces it in this complex.