// Workers AI · dad joke modeWhat did RBM17 say to RBM18? You're a binding mate.

RBM17
Identifiers
Aliases	RBM17, SPF45, RNA binding motif protein 17
External IDs	OMIM: 606935; MGI: 1924188; HomoloGene: 13162; GeneCards: RBM17; OMA:RBM17 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PE8, 2PEH
Gene location (Human)
Chr.	Chromosome 10 (human)
End	6,117,457 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	11,608,964 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; body of uterus; ; body of pancreas; ; spleen; ; right uterine tube; ; right lobe of thyroid gland; ; right lung; ; upper lobe of left lung; ; appendix; ; left uterine tube;
	Top expressed in
	tail of embryo; ; epiblast; ; Ileal epithelium; ; secondary oocyte; ; zygote; ; ventricular zone; ; primary oocyte; ; neural layer of retina; ; genital tubercle; ; renal corpuscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; nucleic acid binding;
Cellular component	spliceosomal complex; nucleus; nucleoplasm; protein-containing complex;
Biological process	mRNA processing; alternative mRNA splicing, via spliceosome; RNA splicing; mRNA splicing, via spliceosome; DNA repair; regulation of RNA splicing; regulation of alternative mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	84991
	76938
	ENSG00000134453
	ENSMUSG00000037197
	Q96I25
	Q8JZX4
	NM_032905; NM_001145547
	NM_152824
	NP_001139019; NP_116294
	NP_690037
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor 45 is a protein that in humans is encoded by the RBM17 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134453 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037197 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Oct 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
↑ "Entrez Gene: RBM17 RNA binding motif protein 17".

Graveley BR (2002). "Sex, AGility, and the regulation of alternative splicing". Cell. 109 (4): 409–12. doi:10.1016/S0092-8674(02)00750-X. PMID 12086596. S2CID 15031931.
Lallena MJ, Chalmers KJ, Llamazares S, et al. (2002). "Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45". Cell. 109 (3): 285–96. doi:10.1016/S0092-8674(02)00730-4. PMID 12015979. S2CID 15734142.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sampath J, Long PR, Shepard RL, et al. (2003). "Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells". Am. J. Pathol. 163 (5): 1781–90. doi:10.1016/S0002-9440(10)63538-9. PMC 1892446. PMID 14578179.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Perry WL, Shepard RL, Sampath J, et al. (2005). "Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators". Cancer Res. 65 (15): 6593–600. doi:10.1158/0008-5472.CAN-03-3675. PMID 16061639.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Chaouki AS, Salz HK (2007). "Drosophila SPF45: a bifunctional protein with roles in both splicing and DNA repair". PLOS Genet. 2 (12): e178. doi:10.1371/journal.pgen.0020178. PMC 1687153. PMID 17154718.
Corsini L, Bonnal S, Bonna S, et al. (2007). "U2AF-homology motif interactions are required for alternative splicing regulation by SPF45". Nat. Struct. Mol. Biol. 14 (7): 620–9. doi:10.1038/nsmb1260. PMID 17589525. S2CID 22784521.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134453 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037197 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9731529-5] Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Oct 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.

[entrez-6] "Entrez Gene: RBM17 RNA binding motif protein 17".

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// Workers AI · dad joke modeWhat did RBM17 say to RBM18? You're a binding mate.

References

Further reading