// Workers AI · dad joke modeWhat did RALY say to its friend? You can RALY on me.

RALY
Identifiers
Aliases	RALY, HNRPCL2, P542, RALY heterogeneous nuclear ribonucleoprotein
External IDs	OMIM: 614663; MGI: 97850; HomoloGene: 7216; GeneCards: RALY; OMA:RALY - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WF1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	34,108,308 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	154,709,181 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; granulocyte; ; ventricular zone; ; right lobe of thyroid gland; ; mucosa of transverse colon; ; left lobe of thyroid gland; ; left testis; ; right testis; ; ascending aorta; ; popliteal artery;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; yolk sac; ; granulocyte; ; lip; ; embryo; ; epiblast; ; tail of embryo; ; embryo; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; transcription coregulator activity; RNA binding;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex; nucleus;
Biological process	mRNA splicing, via spliceosome; mRNA processing; RNA splicing; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of nucleic acid-templated transcription; cholesterol homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	22913
	19383
	ENSG00000125970
	ENSMUSG00000027593
	Q9UKM9
	Q64012
	NM_007367; NM_016732
	NM_001139511; NM_001139512; NM_001139513; NM_023130
	NP_031393; NP_057951
	NP_001132983; NP_001132984; NP_001132985; NP_075619
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein Raly is a protein that in humans is encoded by the RALY gene.^[5]^[6]

In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125970 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027593 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Khrebtukova I, Kuklin A, Woychik RP, Michaud EJ (Nov 1999). "Alternative processing of the human and mouse raly genes(1)". Biochim Biophys Acta. 1447 (1): 107–12. doi:10.1016/s0167-4781(99)00126-8. PMID 10500250.
1 2 "Entrez Gene: RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary". Pituitary. 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684. S2CID 10789246.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Rhodes GH, Valbracht JR, Nguyen MD, Vaughan JH (1997). "The p542 gene encodes an autoantigen that cross-reacts with EBNA-1 of the Epstein Barr virus and which may be a heterogeneous nuclear ribonucleoprotein". J. Autoimmun. 10 (5): 447–54. doi:10.1006/jaut.1997.9996. PMID 9376072.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Vaughan JH, Valbracht JR, Nguyen MD, et al. (1995). "Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1". J. Clin. Invest. 95 (3): 1306–15. doi:10.1172/JCI117781. PMC 441470. PMID 7533788.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000125970 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027593 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10500250-5] Khrebtukova I, Kuklin A, Woychik RP, Michaud EJ (Nov 1999). "Alternative processing of the human and mouse raly genes(1)". Biochim Biophys Acta. 1447 (1): 107–12. doi:10.1016/s0167-4781(99)00126-8. PMID 10500250.

[entrez-6] 1 2 "Entrez Gene: RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))".

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// Workers AI · dad joke modeWhat did RALY say to its friend? You can RALY on me.

References

Further reading