RAB8B

RAB8B
Identifiers
Aliases	RAB8B, member RAS oncogene family
External IDs	OMIM: 613532; MGI: 2442982; HomoloGene: 69220; GeneCards: RAB8B; OMA:RAB8B - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	63,267,776 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	66,826,969 bp
RNA expression pattern
	Top expressed in
	sperm; ; Achilles tendon; ; superficial temporal artery; ; secondary oocyte; ; trabecular bone; ; ventricular zone; ; germinal epithelium; ; monocyte; ; vena cava; ; ganglionic eminence;
	Top expressed in
	stroma of bone marrow; ; mesenteric lymph nodes; ; blood; ; tibiofemoral joint; ; primitive streak; ; fetal liver hematopoietic progenitor cell; ; granulocyte; ; gastrula; ; medial ganglionic eminence; ; calvaria;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleotide binding; signaling receptor binding; GTP binding; TPR domain binding; GDP binding; GTPase activity;
Cellular component	mitochondrion; peroxisomal membrane; cell tip; membrane; phagocytic vesicle membrane; perinuclear region of cytoplasm; cytoplasmic vesicle; phagocytic vesicle; extracellular exosome; nucleoplasm; nuclear body; intracellular membrane-bounded organelle; recycling endosome membrane; endosome; plasma membrane; synaptic vesicle; secretory granule membrane; trans-Golgi network transport vesicle; presynapse;
Biological process	vesicle docking involved in exocytosis; protein secretion; positive regulation of cell projection organization; protein import into peroxisome membrane; antigen processing and presentation; adherens junction organization; positive regulation of corticotropin secretion; protein transport; cilium assembly; protein localization to plasma membrane; regulation of exocytosis; transport; intracellular protein transport; Rab protein signal transduction; cellular response to insulin stimulus; Golgi vesicle fusion to target membrane;
	Sources:Amigo / QuickGO
Orthologs
	51762
	235442
	ENSG00000166128
	ENSMUSG00000036943
	Q92930
	P61028
	NM_016530
	NM_173413
	NP_057614
	NP_775589
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-8B is a protein that in humans is encoded by the RAB8B gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166128 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036943 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chen D, Guo J, Gahl WA (Mar 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
↑ Heidrych P, Zimmermann U, Bress A, Pusch CM, Ruth P, Pfister M, Knipper M, Blin N (Nov 2008). "Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form". Hum Mol Genet. 17 (23): 3814–21. doi:10.1093/hmg/ddn279. PMID 18772196.
↑ "Entrez Gene: RAB8B RAB8B, member RAS oncogene family".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lau AS, Mruk DD (2003). "Rab8B GTPase and junction dynamics in the testis". Endocrinology. 144 (4): 1549–63. doi:10.1210/en.2002-220893. PMID 12639940.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hattula K, Furuhjelm J, Arffman A, Peränen J (2003). "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport". Mol. Biol. Cell. 13 (9): 3268–80. doi:10.1091/mbc.E02-03-0143. PMC 124888. PMID 12221131.
de Bruyn KM, de Rooij J, Wolthuis RM, et al. (2000). "RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral". J. Biol. Chem. 275 (38): 29761–6. doi:10.1074/jbc.M001160200. PMID 10889189.
Armstrong J, Thompson N, Squire JH, et al. (1997). "Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3". J. Cell Sci. 109 (6): 1265–74. doi:10.1242/jcs.109.6.1265. PMID 8799816.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166128 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036943 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9030196-5] Chen D, Guo J, Gahl WA (Mar 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.

[pmid18772196-6] Heidrych P, Zimmermann U, Bress A, Pusch CM, Ruth P, Pfister M, Knipper M, Blin N (Nov 2008). "Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form". Hum Mol Genet. 17 (23): 3814–21. doi:10.1093/hmg/ddn279. PMID 18772196.

[entrez-7] "Entrez Gene: RAB8B RAB8B, member RAS oncogene family".

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RAB8B

References

Further reading