// Workers AI · dad joke modeWhat did RAB3D say to its date? "You're a byte above the rest.

RAB3D
Identifiers
Aliases	RAB3D, D2-2, GOV, RAB16, RAD3D, member RAS oncogene family
External IDs	OMIM: 604350; MGI: 97844; HomoloGene: 20902; GeneCards: RAB3D; OMA:RAB3D - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GF9
Enzyme activity
Gene location (Human)
Chr.	Chromosome 19 (human)
End	11,346,270 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,829,488 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; spinal ganglia; ; human penis; ; nipple; ; skin of thigh; ; mucosa of pharynx; ; vulva; ; blood; ; cardia; ; trigeminal ganglion;
	Top expressed in
	lacrimal gland; ; granulocyte; ; salivary gland; ; lumbar spinal ganglion; ; epithelium of stomach; ; corneal stroma; ; submandibular gland; ; pyloric antrum; ; parotid gland; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; myosin V binding; GTP-dependent protein binding; GTPase activity;
Cellular component	zymogen granule; cytoplasmic microtubule; secretory vesicle; extracellular exosome; transport vesicle; mitochondrion; membrane; plasma membrane; azurophil granule membrane; endosome; synaptic vesicle; vesicle;
Biological process	regulation of exocytosis; protein transport; peptidyl-cysteine methylation; bone resorption; positive regulation of regulated secretory pathway; exocytosis; neutrophil degranulation; transport; intracellular protein transport; vesicle docking involved in exocytosis; protein secretion; Rab protein signal transduction; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	9545
	19340
	ENSG00000105514
	ENSMUSG00000019066
	O95716
	P35276
	NM_004283
	NM_031874; NM_001324531
	NP_004274
	NP_001311460; NP_114080
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-3D is a protein that in humans is encoded by the RAB3D gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105514 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019066 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nishio H, Suda T, Sawada K, Miyamoto T, Koike T, Yamaguchi Y (Mar 1999). "Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation". Biochim Biophys Acta. 1444 (2): 283–90. doi:10.1016/s0167-4781(98)00279-6. PMID 10023084.
↑ Chen XN, Shi ZY, Korenberg JR, Sehgal A (Mar 1999). "Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 230–1. doi:10.1159/000015187. PMID 10072586. S2CID 24430172.
↑ "Entrez Gene: RAB3D RAB3D, member RAS oncogene family".

Brondyk WH, McKiernan CJ, Fortner KA, et al. (1995). "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A". Mol. Cell. Biol. 15 (3): 1137–43. doi:10.1128/MCB.15.3.1137. PMC 230335. PMID 7532276.
Sehgal A, Keener C, Boynton AL, et al. (1997). "Isolation and characterization of a novel gene from human glioblastoma multiforme tumor tissue". Int. J. Cancer. 71 (4): 565–72. doi:10.1002/(SICI)1097-0215(19970516)71:4<565::AID-IJC10>3.0.CO;2-B. PMID 9178809.
Raffaniello RD, Raufman JP (1999). "Cytosolic RAB3D is associated with RAB escort protein (REP), not RAB-GDP dissociation inhibitor (GDI), in dispersed chief cells from guinea pig stomach". J. Cell. Biochem. 72 (4): 540–8. doi:10.1002/(SICI)1097-4644(19990315)72:4<540::AID-JCB9>3.0.CO;2-D. PMID 10022613. S2CID 35820873.
Cartel NJ, Wang J, Post M (2002). "Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt". Biochem. J. 363 (Pt 1): 19–28. doi:10.1042/0264-6021:3630019. PMC 1222446. PMID 11903042.
Riedel D, Antonin W, Fernandez-Chacon R, et al. (2002). "Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules". Mol. Cell. Biol. 22 (18): 6487–97. doi:10.1128/MCB.22.18.6487-6497.2002. PMC 135623. PMID 12192047.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Nguyen D, Jones A, Ojakian GK, et al. (2003). "Rab3D redistribution and function in rat parotid acini". J. Cell. Physiol. 197 (3): 400–8. doi:10.1002/jcp.10373. PMID 14566969. S2CID 33152672.
Matsumoto M, Miki T, Shibasaki T, et al. (2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
Knop M, Aareskjold E, Bode G, Gerke V (2005). "Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells". EMBO J. 23 (15): 2982–92. doi:10.1038/sj.emboj.7600319. PMC 514934. PMID 15257287.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105514 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019066 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10023084-5] Nishio H, Suda T, Sawada K, Miyamoto T, Koike T, Yamaguchi Y (Mar 1999). "Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation". Biochim Biophys Acta. 1444 (2): 283–90. doi:10.1016/s0167-4781(98)00279-6. PMID 10023084.

[pmid10072586-6] Chen XN, Shi ZY, Korenberg JR, Sehgal A (Mar 1999). "Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 230–1. doi:10.1159/000015187. PMID 10072586. S2CID 24430172.

[entrez-7] "Entrez Gene: RAB3D RAB3D, member RAS oncogene family".

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// Workers AI · dad joke modeWhat did RAB3D say to its date? "You're a byte above the rest.

References

Further reading