PncA
| Nicotinamidase/pyrazinamidase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | pncA | ||||||
| UniProt | I6XD65 | ||||||
| |||||||
PncA is a bacterial gene encoding a nicotinamidase that doubles as a pyrazinamidase in Mycobacterium species.[1] Nicotinamidase converts nicotinamide to nicotinic acid where as pyrazinamidase converts the drug pyrazinamide to its active form pyrazinoic acid.[2]
Missense mutations in this gene in Mycobacterium is strongly correlated with resistance to pyrazinamide, likely due to a loss of the ability to produce pyrazinoic acid.[3] Mutagenesis data indicates that many loss-of-function mutations differentially affect the enzyme's ability to convert nicotinamide and pyrazinamide.[4]
The H57D resistance mutation is "typical of" M. bovis.[3]
The symbol PncA is also used for the orthologous nicotinamidase in other bacterial species, including E. coli.[5]
See also
[edit]References
[edit]- ↑ Scorpio A, Zhang Y (June 1996). "Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus". Nat. Med. 2 (6): 662–7. doi:10.1038/nm0696-662. PMID 8640557. S2CID 8579133.
- ↑ Whitfield, Michael G.; Soeters, Heidi M.; Warren, Robin M.; York, Talita; Sampson, Samantha L.; Streicher, Elizabeth M.; Helden, Paul D. van; Rie, Annelies van (2015-07-28). "A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis". PLOS ONE. 10 (7) e0133869. Bibcode:2015PLoSO..1033869W. doi:10.1371/journal.pone.0133869. ISSN 1932-6203. PMC 4517823. PMID 26218737.
- 1 2 Juréen, Pontus; Werngren, Jim; Toro, Juan-Carlos; Hoffner, Sven (2016-12-15). "Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis". Antimicrobial Agents and Chemotherapy. 52 (5): 1852–1854. doi:10.1128/AAC.00110-08. ISSN 0066-4804. PMC 2346646. PMID 18316515.
- ↑ "I6XD65". UniProt.
- ↑ "P21369". UniProt.
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