PYGO2

PYGO2
Identifiers
Aliases	PYGO2, 1190004M21Rik, pygopus family PHD finger 2
External IDs	OMIM: 606903; MGI: 1916161; HomoloGene: 44519; GeneCards: PYGO2; OMA:PYGO2 - orthologs
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2XB1, 4UP0, 4UP5
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 154,957,026 bp End 154,963,853 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F1 Start 89,337,521 bp End 89,342,435 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm cardiac muscle tissue of right atrium myocardium of left ventricle nasal epithelium cardia right adrenal gland anterior pituitary right adrenal cortex granulocyte oocyte Top expressed in papillary dermis yolk sac granulocyte dermal papilla cumulus cell gastrula ventricular zone lens epiblast lip More reference expression data BioGPS n/a
Gene ontology Molecular function histone binding metal ion binding protein binding chromatin binding histone acetyltransferase regulator activity Cellular component nucleoplasm nucleus beta-catenin-TCF complex Biological process roof of mouth development regulation of histone H3-K4 methylation in utero embryonic development regulation of mammary gland epithelial cell proliferation positive regulation of chromatin binding mammary gland development brain development lens development in camera-type eye developmental growth regulation of histone acetylation spermatid development canonical Wnt signaling pathway beta-catenin-TCF complex assembly kidney development spermatid nucleus differentiation post-embryonic development Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90780 68911 Ensembl ENSG00000163348 ENSMUSG00000047824 UniProt Q9BRQ0 n/a RefSeq (mRNA) NM_138300 NM_001293763 NM_001293766 NM_001293767 NM_001293768 NM_026869 RefSeq (protein) NP_612157 n/a Location (UCSC) Chr 1: 154.96 – 154.96 Mb Chr 3: 89.34 – 89.34 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Pygopus homolog 2 is a protein that in humans is encoded by the PYGO2 gene.

Further reading

• Kramps T, Peter O, Brunner E, et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex" (PDF). Cell. 109 (1): 47–60. doi:10.1016/S0092-8674(02)00679-7. PMID 11955446. S2CID 16720801. Archived from the original (PDF) on 2021-09-26. Retrieved 2021-01-31.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Townsley FM, Thompson B, Bienz M (2004). "Pygopus residues required for its binding to Legless are critical for transcription and development". J. Biol. Chem. 279 (7): 5177–83. doi:10.1074/jbc.M309722200. PMID 14612447. S2CID 6880212.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Popadiuk CM, Xiong J, Wells MG, et al. (2006). "Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer". Clin. Cancer Res. 12 (7 Pt 1): 2216–23. doi:10.1158/1078-0432.CCR-05-2433. PMID 16609037. S2CID 3260972.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Hoffmans R, Basler K (2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling". Mech. Dev. 124 (1): 59–67. doi:10.1016/j.mod.2006.09.006. PMID 17113272. S2CID 17642255.
• Andrews PG, Lake BB, Popadiuk C, Kao KR (2007). "Requirement of Pygopus 2 in breast cancer". Int. J. Oncol. 30 (2): 357–63. doi:10.3892/ijo.30.2.357 (inactive 12 July 2025). PMID 17203217.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)