// Workers AI · dad joke modeWhat did PPIH say to its date? You're a pixel-fect match.

PPIH
Identifiers
Aliases	PPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H
External IDs	OMIM: 606095; MGI: 106499; HomoloGene: 38172; GeneCards: PPIH; OMA:PPIH - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MZW, 1QOI
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	42,676,758 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	119,177,743 bp
RNA expression pattern
	Top expressed in
	embryo; ; ventricular zone; ; ganglionic eminence; ; mucosa of transverse colon; ; granulocyte; ; secondary oocyte; ; rectum; ; mucosa of esophagus; ; olfactory zone of nasal mucosa; ; lymph node;
	Top expressed in
	ventricular zone; ; embryo; ; spermatocyte; ; embryo; ; yolk sac; ; morula; ; blastocyst; ; spermatid; ; genital tubercle; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ribonucleoprotein complex binding; isomerase activity; protein binding; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding; unfolded protein binding;
Cellular component	cytoplasm; nuclear speck; U4/U6 x U5 tri-snRNP complex; spliceosomal complex; nucleus; nucleoplasm; U4/U6 snRNP;
Biological process	mRNA splicing, via spliceosome; mRNA processing; positive regulation of viral genome replication; protein folding; RNA splicing; protein-containing complex assembly; protein peptidyl-prolyl isomerization; angiogenesis; protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	10465
	66101
	ENSG00000171960
	ENSMUSG00000060288
	O43447
	Q9D868
	NM_006347; NM_001330510
	NM_001110129; NM_001110130; NM_028677
	NP_001317439; NP_006338
	NP_001103599; NP_001103600; NP_082953
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171960 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060288 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC 1369579. PMID 9404889.
↑ Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R (May 1998). "The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins". RNA. 4 (2): 127–41. PMC 1369602. PMID 9570313.
1 2 "Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H)".

Reidt U, Reuter K, Achsel T, et al. (2000). "Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin" (PDF). J. Biol. Chem. 275 (11): 7439–42. doi:10.1074/jbc.275.11.7439. PMID 10713041. S2CID 20261807.
Horowitz DS, Lee EJ, Mabon SA, Misteli T (2002). "A cyclophilin functions in pre-mRNA splicing". EMBO J. 21 (3): 470–80. doi:10.1093/emboj/21.3.470. PMC 125845. PMID 11823439.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Reidt U, Wahl MC, Fasshauer D, et al. (2003). "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". J. Mol. Biol. 331 (1): 45–56. doi:10.1016/S0022-2836(03)00684-3. hdl:11858/00-001M-0000-0012-F238-B. PMID 12875835.
Ingelfinger D, Göthel SF, Marahiel MA, et al. (2004). "Two protein–protein interaction sites on the spliceosome-associated human cyclophilin CypH". Nucleic Acids Res. 31 (16): 4791–6. doi:10.1093/nar/gkg660. PMC 169899. PMID 12907720.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171960 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060288 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9404889-5] Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC 1369579. PMID 9404889.

[pmid9570313-6] Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R (May 1998). "The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins". RNA. 4 (2): 127–41. PMC 1369602. PMID 9570313.

[entrez-7] 1 2 "Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H)".

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References

Further reading