PLXNB2

PLXNB2
Identifiers
Aliases	PLXNB2, MM1, Nbla00445, PLEXB2, dJ402G11.3, plexin B2
External IDs	OMIM: 604293; MGI: 2154239; HomoloGene: 66630; GeneCards: PLXNB2; OMA:PLXNB2 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4E71
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.33 Start 50,274,979 bp End 50,307,646 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 E3|15 44.68 cM Start 89,039,752 bp End 89,064,991 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right hemisphere of cerebellum right lobe of thyroid gland left lobe of thyroid gland anterior pituitary stromal cell of endometrium nasal epithelium body of stomach olfactory zone of nasal mucosa decidua Top expressed in pyloric antrum choroid plexus of fourth ventricle calvaria corneal stroma genital tubercle epithelium of stomach stroma of bone marrow ventricular zone conjunctival fornix Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding semaphorin receptor activity Cellular component integral component of membrane membrane plasma membrane cell surface extracellular exosome integral component of plasma membrane semaphorin receptor complex Biological process regulation of protein phosphorylation negative regulation of cell adhesion regulation of GTPase activity positive regulation of axonogenesis multicellular organism development neural tube closure brain development regulation of cell shape neuroblast proliferation regulation of neuron migration semaphorin-plexin signaling pathway signal transduction positive regulation of neuron projection development homophilic cell adhesion via plasma membrane adhesion molecules regulation of cell migration semaphorin-plexin signaling pathway involved in axon guidance excitatory synapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23654 140570 Ensembl ENSG00000196576 ENSMUSG00000036606 UniProt O15031 B2RXS4 RefSeq (mRNA) NM_012401 NM_001159521 NM_001284506 NM_138749 RefSeq (protein) NP_036533 NP_001363793 NP_001363794 NP_001363795 NP_001363796 NP_001363797 NP_001363798 NP_001363799 NP_001363800 NP_001363801 NP_001363802 NP_001363803 NP_001363804 NP_001363805 NP_001363806 NP_001363807 NP_001363808 NP_001363809 NP_001363810 NP_001363811 NP_001363812 NP_001363813 NP_001363814 NP_001363815 NP_001152993 NP_001271435 NP_620088 Location (UCSC) Chr 22: 50.27 – 50.31 Mb Chr 15: 89.04 – 89.06 Mb PubMed search
Wikidata
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Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.

Function

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM]

Interactions

PLXNB2 has been shown to interact with ARHGEF11.

Further reading

• Shinoura N, Shamraj OI, Hugenholz H, Zhu JG, McBlack P, Warnick R, Tew JJ, Wani MA, Menon AG (1995). "Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors". Cancer Lett. 89 (2): 215–21. doi:10.1016/0304-3835(95)03690-X. PMID 7889532.
• Trofatter JA, Long KR, Murrell JR, Stotler CJ, Gusella JF, Buckler AJ (1996). "An expression-independent catalog of genes from human chromosome 22". Genome Res. 5 (3): 214–24. doi:10.1101/gr.5.3.214. PMID 8593609.
• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003). "Functional regulation of semaphorin receptors by proprotein convertases". J. Biol. Chem. 278 (12): 10094–101. doi:10.1074/jbc.M210156200. PMID 12533544.
• Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene. 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID 15184888.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.