PLEK2

PLEK2
Identifiers
Aliases	PLEK2, pleckstrin 2
External IDs	OMIM: 608007; MGI: 1351466; HomoloGene: 8447; GeneCards: PLEK2; OMA:PLEK2 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X1G
Gene location (Human)
Chr.	Chromosome 14 (human)
End	67,412,167 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	78,953,738 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; mucosa of transverse colon; ; right adrenal cortex; ; gingival epithelium; ; left adrenal gland; ; left adrenal cortex; ; corpus epididymis; ; rectum; ; jejunal mucosa;
	Top expressed in
	Paneth cell; ; molar; ; fetal liver hematopoietic progenitor cell; ; lumbar spinal ganglion; ; gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach; ; pyloric antrum; ; duodenum; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding;
Cellular component	cytoplasm; plasma membrane; cell projection; lamellipodium membrane; cytoskeleton; membrane;
Biological process	intracellular signal transduction; actin cytoskeleton organization; positive regulation of cell projection organization; actin cytoskeleton reorganization; positive regulation of plasma membrane bounded cell projection assembly;
	Sources:Amigo / QuickGO
Orthologs
	26499
	27260
	ENSG00000100558
	ENSMUSG00000021118
	Q9NYT0
	Q9WV52
	NM_016445
	NM_013738
	NP_057529
	NP_038766
	Wikidata
View/Edit Human	View/Edit Mouse

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene.^[5]^[6]^[7] The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100558 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021118 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lemmon, Mark A.; Ferguson, Kathryn M.; Abrams, Charles S. (2002). "Pleckstrin homology domains and the cytoskeleton". FEBS Letters. 513 (1): 71–76. doi:10.1016/S0014-5793(01)03243-4. PMID 11911883.
↑ Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y (Aug 2007). "Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading". Biochem Biophys Res Commun. 361 (2): 270–5. doi:10.1016/j.bbrc.2007.06.132. PMID 17658464.
↑ "Entrez Gene: PLEK2 pleckstrin 2".
↑ "AceView: PLEK2 gene". AceView. National Library of Medicine. Retrieved 24 April 2011.

Bach TL, Kerr WT, Wang Y, et al. (2007). "PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization". Blood. 109 (3): 1147–55. doi:10.1182/blood-2006-02-001339. PMC 1785144. PMID 17008542.
Inazu T, Kuroiwa A, Matsuda Y, Miyamoto K (2005). "Cloning, expression and chromosomal assignment of human pleckstrin 2". Mol. Biol. Rep. 32 (1): 35–40. doi:10.1007/s11033-004-4747-x. PMID 15865208. S2CID 8131790.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Inazu T, Yamada K, Miyamoto K (1999). "Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family". Biochem. Biophys. Res. Commun. 265 (1): 87–93. doi:10.1006/bbrc.1999.1461. PMID 10548495.
Hu MH, Bauman EM, Roll RL, et al. (1999). "Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement". J. Biol. Chem. 274 (31): 21515–8. doi:10.1074/jbc.274.31.21515. PMID 10419454.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100558 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021118 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11911883-5] Lemmon, Mark A.; Ferguson, Kathryn M.; Abrams, Charles S. (2002). "Pleckstrin homology domains and the cytoskeleton". FEBS Letters. 513 (1): 71–76. doi:10.1016/S0014-5793(01)03243-4. PMID 11911883.

[pmid17658464-6] Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y (Aug 2007). "Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading". Biochem Biophys Res Commun. 361 (2): 270–5. doi:10.1016/j.bbrc.2007.06.132. PMID 17658464.

[entrez-7] "Entrez Gene: PLEK2 pleckstrin 2".

[AceView-8] "AceView: PLEK2 gene". AceView. National Library of Medicine. Retrieved 24 April 2011.

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PLEK2

References

Further reading