PIK3R6

PIK3R6
Identifiers
Aliases	PIK3R6, C17orf38, HsT41028, p84 PIKAP, p87(PIKAP), p87PIKAP, phosphoinositide-3-kinase regulatory subunit 6
External IDs	OMIM: 611462; MGI: 2144613; GeneCards: PIK3R6
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,867,677 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	68,443,524 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; testicle; ; spleen; ; appendix; ; apex of heart; ; blood; ; gonad; ; gallbladder; ; lymph node;
	Top expressed in
	granulocyte; ; carotid body; ; renal corpuscle; ; lumbar spinal ganglion; ; bone marrow; ; Paneth cell; ; morula; ; substantia nigra; ; central gray substance of midbrain; ; nucleus of stria terminalis;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytoplasm; cytosol; plasma membrane; phosphatidylinositol 3-kinase complex, class IB; membrane; phosphatidylinositol 3-kinase complex;
Biological process	platelet activation; positive regulation of T cell differentiation; phosphatidylinositol phosphate biosynthetic process; regulation of phosphatidylinositol 3-kinase activity; angiogenesis; positive regulation of angiogenesis; regulation of natural killer cell mediated cytotoxicity; phosphatidylinositol 3-kinase signaling; positive regulation of MAP kinase activity; G protein-coupled receptor signaling pathway; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	146850
	104709
	ENSG00000276231
	ENSMUSG00000046207
	Q5UE93
	Q3U6Q4
	NM_001010855; NM_001290211
	NM_001004435; NM_001081566
	NP_001010855; NP_001277140
	NP_001004435; NP_001075035
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoinositide 3-kinase regulatory subunit 6 (also called p87^PIKAP) is a protein that in humans is encoded by the PIK3R6 gene.^[5] The PIK3R6 protein is a regulatory subunit of phosphoinositide 3-kinase-γ (PI3Kγ), which functions as an enzyme (a lipid kinase) that is activated by membrane receptors.^[5] PIK3R6 is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.^[6] It is also referred to as p84 and p87.^[7] Some studies have found PIK3R6 to have a role in carcinogenesis.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000276231 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046207 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 [ Homo sapiens (human) ]". ncbi.nlm.nih.gov. 2026-08-05. Retrieved 2026-08-19.
↑ Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.
↑ Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. Bibcode:2009PNAS..10620312K. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.
↑ Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31 (18): 2350–2361. doi:10.1038/onc.2011.414. PMID 21996737. S2CID 24708435.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000276231 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046207 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 [ Homo sapiens (human) ]". ncbi.nlm.nih.gov. 2026-08-05. Retrieved 2026-08-19.

[pmid16476736-6] Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.

[pmid19906996-7] Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. Bibcode:2009PNAS..10620312K. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.

[8] Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31 (18): 2350–2361. doi:10.1038/onc.2011.414. PMID 21996737. S2CID 24708435.

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PIK3R6

References