PIGF

PIGF
Identifiers
Aliases	PIGF, phosphatidylinositol glycan anchor biosynthesis class F, OORS
External IDs	OMIM: 600153; MGI: 99462; HomoloGene: 31103; GeneCards: PIGF; OMA:PIGF - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p21 Start 46,580,937 bp End 46,617,055 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 E4|17 56.9 cM Start 87,304,684 bp End 87,332,834 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte islet of Langerhans right adrenal gland rectum right adrenal cortex left adrenal gland left adrenal cortex mucosa of transverse colon monocyte stromal cell of endometrium Top expressed in spermatid secondary oocyte zygote spermatocyte seminiferous tubule primary oocyte Paneth cell epithelium of stomach primitive streak yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ethanolaminephosphotransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5281 18701 Ensembl ENSG00000151665 ENSMUSG00000024145 UniProt Q07326 O09101 RefSeq (mRNA) NM_002643 NM_173074 NM_008838 RefSeq (protein) NP_002634 NP_775097 NP_032864 Location (UCSC) Chr 2: 46.58 – 46.62 Mb Chr 17: 87.3 – 87.33 Mb PubMed search
Wikidata
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Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.

Function

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least two alternatively spliced transcripts encoding distinct isoforms have been found for this gene.

See also

• VEGF

Further reading

• Kinoshita T, Takahashi M, Inoue N, Miyata T, Takeda J (Feb 1994). "Expression cloning of genes for GPI-anchor biosynthesis". Brazilian Journal of Medical and Biological Research. 27 (2): 127–132. PMID 8081220.
• Hong Y, Maeda Y, Watanabe R, Inoue N, Ohishi K, Kinoshita T (Jul 2000). "Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol". The Journal of Biological Chemistry. 275 (27): 20911–20919. doi:10.1074/jbc.M001913200. PMID 10781593.
• Shishioh N, Hong Y, Ohishi K, Ashida H, Maeda Y, Kinoshita T (Mar 2005). "GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol". The Journal of Biological Chemistry. 280 (10): 9728–9734. doi:10.1074/jbc.M413755200. PMID 15632136.
• Li W, Shen W, Gill R, Corbly A, Jones B, Belagaje R, Zhang Y, Tang S, Chen Y, Zhai Y, Wang G, Wagle A, Hui K, Westmore M, Hanson J, Chen YF, Simons M, Singh J (May 2006). "High-resolution quantitative computed tomography demonstrating selective enhancement of medium-size collaterals by placental growth factor-1 in the mouse ischemic hindlimb". Circulation. 113 (20): 2445–2453. doi:10.1161/CIRCULATIONAHA.105.586818. PMID 16702473.
• Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC (Jun 2006). "Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality" (PDF). The Journal of Experimental Medicine. 203 (6): 1447–1458. doi:10.1084/jem.20060375. PMC 2118329. PMID 16702604.
• Zheng Y, Murakami M, Takahashi H, Yamauchi M, Kiba A, Yamaguchi S, Yabana N, Alitalo K, Shibuya M (Sep 2006). "Chimeric VEGF-E(NZ7)/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation". Arteriosclerosis, Thrombosis, and Vascular Biology. 26 (9): 2019–2026. doi:10.1161/01.ATV.0000233336.53574.a1. PMID 16794222.
• Mohammed KA, Nasreen N, Tepper RS, Antony VB (Feb 2007). "Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release". American Journal of Physiology. Lung Cellular and Molecular Physiology. 292 (2): L559–566. doi:10.1152/ajplung.00075.2006. PMID 17028267.