PIBF1

PIBF1
Identifiers
Aliases	PIBF1, C13orf24, CEP90, PIBF, progesterone immunomodulatory binding factor 1, JBTS33
External IDs	OMIM: 607532; MGI: 1261910; HomoloGene: 4628; GeneCards: PIBF1; OMA:PIBF1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	99,491,929 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; bronchial epithelial cell; ; ganglionic eminence; ; right lobe of thyroid gland; ; stromal cell of endometrium; ; right uterine tube; ; left lobe of thyroid gland; ; anterior pituitary; ; canal of the cervix;
	Top expressed in
	spermatocyte; ; spermatid; ; zygote; ; genital tubercle; ; tail of embryo; ; secondary oocyte; ; seminiferous tubule; ; morula; ; blastocyst; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-4 receptor binding; protein binding;
Cellular component	cytoplasm; centrosome; centriolar satellite; extracellular region; cytoskeleton; nucleus; extracellular space; microtubule organizing center;
Biological process	negative regulation of natural killer cell activation; positive regulation of interleukin-10 production; immune system process; mitotic spindle assembly; protein localization to centrosome; mitotic metaphase plate congression; negative regulation of prostaglandin biosynthetic process; negative regulation of interleukin-12 production; non-motile cilium assembly; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of tyrosine phosphorylation of STAT protein; activation of Janus kinase activity; cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	10464
	52023
	n/a
	ENSMUSG00000022064
	Q8WXW3
	n/a
	NM_006346; NM_001349655
	NM_029320; NM_029454
	NP_006337; NP_001336584
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Progesterone-induced-blocking factor 1 is a protein that in humans is encoded by the PIBF1 gene.^[4]^[5] It has been shown to localize to the centrosome^[6] and has also been named CEP90.^[7]

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022064 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rozenblum E, Vahteristo P, Sandberg T, Bergthorsson JT, Syrjakoski K, Weaver D, et al. (April 2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Human Genetics. 110 (2): 111–121. doi:10.1007/s00439-001-0646-6. PMID 11935316. S2CID 21371347.
↑ "Entrez Gene: C13orf24 chromosome 13 open reading frame 24".
↑ Lachmann M, Gelbmann D, Kálmán E, Polgár B, Buschle M, Von Gabain A, et al. (October 2004). "PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome". International Journal of Cancer. 112 (1): 51–60. doi:10.1002/ijc.20326. PMID 15305375.
↑ Kim K, Rhee K (February 2011). "The pericentriolar satellite protein CEP90 is crucial for integrity of the mitotic spindle pole". Journal of Cell Science. 124 (Pt 3): 338–347. doi:10.1242/jcs.078329. PMID 21224392. S2CID 12306606.

External links

Human PIBF1 genome location and PIBF1 gene details page in the UCSC Genome Browser.

Szekeres-Bartho J, Barakonyi A, Par G, Polgar B, Palkovics T, Szereday L (June 2001). "Progesterone as an immunomodulatory molecule". International Immunopharmacology. 1 (6): 1037–1048. doi:10.1016/S1567-5769(01)00035-2. PMID 11407300.
Szekeres-Bartho J, Varga P, Pejtsik B (1990). "ELISA test for the detection of an immunological blocking factor in human pregnancy serum". Journal of Reproductive Immunology. 16 (1): 19–29. doi:10.1016/0165-0378(89)90003-X. PMID 2600930.
Szekeres-Bartho J, Faust Z, Varga P (1996). "The expression of a progesterone-induced immunomodulatory protein in pregnancy lymphocytes". American Journal of Reproductive Immunology. 34 (6). New York: 342–348. doi:10.1111/j.1600-0897.1995.tb00962.x. PMID 8607938. S2CID 6397686.
Check JH, Arwitz M, Gross J, Peymer M, Szekeres-Bartho J (January 1997). "Lymphocyte immunotherapy (LI) increases serum levels of progesterone induced blocking factor (PIBF)". American Journal of Reproductive Immunology. 37 (1). New York: 17–20. doi:10.1111/j.1600-0897.1997.tb00188.x. PMID 9138449. S2CID 19773974.
Check JH, Arwitz M, Gross J, Szekeres-Bartho J, Wu CH (July 1997). "Evidence that the expression of progesterone-induced blocking factor by maternal T-lymphocytes is positively correlated with conception". American Journal of Reproductive Immunology. 38 (1). New York: 6–8. doi:10.1111/j.1600-0897.1997.tb00269.x. PMID 9266004. S2CID 26240194.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, et al. (May 2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nature Biotechnology. 19 (5): 440–445. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Polgar B, Kispal G, Lachmann M, Paar C, Nagy E, Csere P, et al. (December 2003). "Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor". Journal of Immunology. 171 (11). Baltimore: 5956–5963. doi:10.4049/jimmunol.171.11.5956. PMID 14634107.
Polgár B, Nagy E, Mikó E, Varga P, Szekeres-Barthó J (November 2004). "Urinary progesterone-induced blocking factor concentration is related to pregnancy outcome". Biology of Reproduction. 71 (5): 1699–1705. doi:10.1095/biolreprod.104.030437. PMID 15269099.
Kozma N, Halasz M, Palkovics T, Szekeres-Bartho J (2006). "The progesterone-induced blocking factor modulates the balance of PKC and intracellular Ca". American Journal of Reproductive Immunology. 55 (2). New York: 122–129. doi:10.1111/j.1600-0897.2005.00337.x. PMID 16433831. S2CID 32668565.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by adding missing information.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022064 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11935316-4] Rozenblum E, Vahteristo P, Sandberg T, Bergthorsson JT, Syrjakoski K, Weaver D, et al. (April 2002). "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes". Human Genetics. 110 (2): 111–121. doi:10.1007/s00439-001-0646-6. PMID 11935316. S2CID 21371347.

[entrez-5] "Entrez Gene: C13orf24 chromosome 13 open reading frame 24".

[6] Lachmann M, Gelbmann D, Kálmán E, Polgár B, Buschle M, Von Gabain A, et al. (October 2004). "PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome". International Journal of Cancer. 112 (1): 51–60. doi:10.1002/ijc.20326. PMID 15305375.

[7] Kim K, Rhee K (February 2011). "The pericentriolar satellite protein CEP90 is crucial for integrity of the mitotic spindle pole". Journal of Cell Science. 124 (Pt 3): 338–347. doi:10.1242/jcs.078329. PMID 21224392. S2CID 12306606.

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v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 LCK PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

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PIBF1

References

External links

Further reading