// Workers AI · dad joke modeWhat did PGM2 say to PGM1? You're one gene behind.

PGM2
Identifiers
Aliases	PGM2, MSTP006, phosphoglucomutase 2
External IDs	OMIM: 172000; MGI: 97564; HomoloGene: 6693; GeneCards: PGM2; OMA:PGM2 - orthologs
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 5.4.2.2 ↗ ↗ ↗ ↗ 5.4.2.7 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 4 (human) Band 4p14 Start 37,826,660 bp End 37,862,937 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 C3.1|5 32.8 cM Start 64,092,950 bp End 64,128,351 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium pancreatic epithelial cell oral cavity germinal epithelium parietal pleura mucosa of pharynx epithelium of nasopharynx visceral pleura human penis secondary oocyte Top expressed in duodenum jejunum gastrula endothelial cell of lymphatic vessel gastric mucosa mucous cell of stomach granulocyte epithelium of stomach pyloric antrum ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding isomerase activity intramolecular transferase activity, phosphotransferases magnesium ion binding protein binding phosphopentomutase activity phosphoglucomutase activity Cellular component extracellular exosome cytoplasm cytosol extracellular region secretory granule lumen ficolin-1-rich granule lumen Biological process glycogen catabolic process galactose catabolic process pentose-phosphate shunt organic substance metabolic process deoxyribose phosphate catabolic process glycogen biosynthetic process glucose metabolic process neutrophil degranulation carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55276 66681 Ensembl ENSG00000169299 ENSMUSG00000029171 UniProt Q96G03 Q7TSV4 RefSeq (mRNA) NM_018290 NM_025700 NM_001356964 RefSeq (protein) NP_060760 NP_079976 NP_001343893 Location (UCSC) Chr 4: 37.83 – 37.86 Mb Chr 5: 64.09 – 64.13 Mb PubMed search
Wikidata
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Phosphoglucomutase-2 is an enzyme that in humans is encoded by the PGM2 gene. PGM2 is a major isozyme in red blood cells.

Further reading

• Sparkes RS, Mohandas T, Sparkes MC, Shulkin JD (1978). "Regional localization of human phosphoglucomutase-2 locus on chromosome 4". Exp. Cell Res. 111 (2): 492–5. doi:10.1016/0014-4827(78)90200-8. PMID 564278.
• Francke U, Brown S (1979). "Regional assignment of genes for phosphoglucomutase2 and peptidase S to 4pter leads to 4q21 in man". Cytogenet. Cell Genet. 22 (1–6): 401–5. doi:10.1159/000130982. PMID 752511.
• Sparkes RS, Mohandas T, Sparkes MC, Shulkin JD (1979). "Human PGM2 (E.C. 2.7.5.1) mapped to 4pter leads to 4q25". Cytogenet. Cell Genet. 22 (1–6): 406–7. doi:10.1159/000130983. PMID 752512.
• Wijnen LM, Grzeschik KH, Pearson PL, Meera Khan P (1977). "The human PGM-2 and its chromosomal localization in man-mouse hybrids". Hum. Genet. 37 (3): 271–8. doi:10.1007/BF00393608. PMID 885546. S2CID 33293909.
• McAlpine PJ, Mohandas T, Komarnicki L, et al. (1976). "Further data on the assignment of the phosphoglucomutase2 (PGM2) gene locus to chromosome 4 in man". Cytogenet. Cell Genet. 14 (3–6): 368–9. doi:10.1159/000130386. PMID 1192820.
• McAlpine PJ, Mohandas T, Komarnicki L, et al. (1976). "Further data on the assignment of the phosphoglucomutase (PGM2) gene locus to chromosome 4 in man". Birth Defects Orig. Artic. Ser. 11 (3): 198–9. PMID 1203483.
• Hopkinson DA, Harris H (1966). "Evidence for a second "structural" locus determining human phosphoglucomutase". Nature. 208 (5008): 410–2. doi:10.1038/208410a0. PMID 5885461. S2CID 4187305.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Maliekal P, Sokolova T, Vertommen D, et al. (2007). "Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family". J. Biol. Chem. 282 (44): 31844–51. doi:10.1074/jbc.M706818200. PMID 17804405.