PGM2

PGM2
Identifiers
Aliases	PGM2, MSTP006, phosphoglucomutase 2
External IDs	OMIM: 172000; MGI: 97564; GeneCards: PGM2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	37,862,937 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	64,128,351 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; pancreatic epithelial cell; ; oral cavity; ; germinal epithelium; ; parietal pleura; ; mucosa of pharynx; ; epithelium of nasopharynx; ; visceral pleura; ; human penis; ; secondary oocyte;
	Top expressed in
	duodenum; ; jejunum; ; gastrula; ; endothelial cell of lymphatic vessel; ; gastric mucosa; ; mucous cell of stomach; ; granulocyte; ; epithelium of stomach; ; pyloric antrum; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; isomerase activity; intramolecular transferase activity, phosphotransferases; magnesium ion binding; protein binding; phosphopentomutase activity; phosphoglucomutase activity;
Cellular component	extracellular exosome; cytoplasm; cytosol; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen;
Biological process	glycogen catabolic process; galactose catabolic process; pentose-phosphate shunt; organic substance metabolic process; deoxyribose phosphate catabolic process; glycogen biosynthetic process; glucose metabolic process; neutrophil degranulation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55276
	66681
	ENSG00000169299
	ENSMUSG00000029171
	Q96G03
	Q7TSV4
	NM_018290
	NM_025700; NM_001356964
	NP_060760
	NP_079976; NP_001343893
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoglucomutase-2 is an enzyme that in humans is encoded by the PGM2 gene.^[5]^[6] PGM2 is a major isozyme in red blood cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169299 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029171 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Whitehouse DB, Tomkins J, Lovegrove JU, Hopkinson DA, McMillan WO (May 1998). "A phylogenetic approach to the identification of phosphoglucomutase genes". Mol Biol Evol. 15 (4): 456–62. doi:10.1093/oxfordjournals.molbev.a025942. PMID 9549096.
↑ "Entrez Gene: PGM2 phosphoglucomutase 2".

Sparkes RS, Mohandas T, Sparkes MC, Shulkin JD (1978). "Regional localization of human phosphoglucomutase-2 locus on chromosome 4". Exp. Cell Res. 111 (2): 492–5. doi:10.1016/0014-4827(78)90200-8. PMID 564278.
Francke U, Brown S (1979). "Regional assignment of genes for phosphoglucomutase2 and peptidase S to 4pter leads to 4q21 in man". Cytogenet. Cell Genet. 22 (1–6): 401–5. doi:10.1159/000130982. PMID 752511.
Sparkes RS, Mohandas T, Sparkes MC, Shulkin JD (1979). "Human PGM2 (E.C. 2.7.5.1) mapped to 4pter leads to 4q25". Cytogenet. Cell Genet. 22 (1–6): 406–7. doi:10.1159/000130983. PMID 752512.
Wijnen LM, Grzeschik KH, Pearson PL, Meera Khan P (1977). "The human PGM-2 and its chromosomal localization in man-mouse hybrids". Hum. Genet. 37 (3): 271–8. doi:10.1007/BF00393608. PMID 885546. S2CID 33293909.
McAlpine PJ, Mohandas T, Komarnicki L, et al. (1976). "Further data on the assignment of the phosphoglucomutase2 (PGM2) gene locus to chromosome 4 in man". Cytogenet. Cell Genet. 14 (3–6): 368–9. doi:10.1159/000130386. PMID 1192820.
McAlpine PJ, Mohandas T, Komarnicki L, et al. (1976). "Further data on the assignment of the phosphoglucomutase (PGM2) gene locus to chromosome 4 in man". Birth Defects Orig. Artic. Ser. 11 (3): 198–9. PMID 1203483.
Hopkinson DA, Harris H (1966). "Evidence for a second "structural" locus determining human phosphoglucomutase". Nature. 208 (5008): 410–2. doi:10.1038/208410a0. PMID 5885461. S2CID 4187305.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Maliekal P, Sokolova T, Vertommen D, et al. (2007). "Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family". J. Biol. Chem. 282 (44): 31844–51. doi:10.1074/jbc.M706818200. PMID 17804405.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000169299 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029171 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9549096-5] Whitehouse DB, Tomkins J, Lovegrove JU, Hopkinson DA, McMillan WO (May 1998). "A phylogenetic approach to the identification of phosphoglucomutase genes". Mol Biol Evol. 15 (4): 456–62. doi:10.1093/oxfordjournals.molbev.a025942. PMID 9549096.

[entrez-6] "Entrez Gene: PGM2 phosphoglucomutase 2".

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PGM2

References

Further reading