PDLIM4

PDLIM4
Identifiers
Aliases	PDLIM4, RIL, PDZ and LIM domain 4
External IDs	OMIM: 603422; MGI: 1353470; HomoloGene: 2735; GeneCards: PDLIM4; OMA:PDLIM4 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EEG, 2V1W, 4Q2O
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.1 Start 132,257,696 bp End 132,273,454 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B1.3|11 32.13 cM Start 53,945,754 bp End 53,959,840 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube body of uterus tibial nerve muscle layer of sigmoid colon cartilage tissue skin of leg gastric mucosa skin of abdomen ascending aorta Descending thoracic aorta Top expressed in lip body wall condyle uterus epithelium of stomach stroma of bone marrow calvaria ankle joint molar cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding protein phosphatase binding protein homodimerization activity alpha-actinin binding actin binding muscle alpha-actinin binding Cellular component stress fiber early endosome lumen filamentous actin recycling endosome lumen postsynaptic membrane nucleus cytoplasm endosome cytoskeleton membrane lamellipodium cell junction early endosome membrane cell projection neuron projection dendritic spine synapse perinuclear region of cytoplasm recycling endosome membrane Z discdkac Biological process actin cytoskeleton reorganization excitatory chemical synaptic transmission development of the heart actin cytoskeleton organization muscle structure development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8572 30794 Ensembl ENSG00000131435 ENSMUSG00000020388 UniProt P50479 P70271 RefSeq (mRNA) NM_003687 NM_001131027 NM_019417 RefSeq (protein) NP_001124499 NP_003678 NP_062290 Location (UCSC) Chr 5: 132.26 – 132.27 Mb Chr 11: 53.95 – 53.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

PDZ and LIM domain protein 4 is a protein that in humans is encoded by the PDLIM4 gene.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cuppen E, van Ham M, Wansink DG, et al. (2000). "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL". Eur. J. Cell Biol. 79 (4): 283–93. doi:10.1078/S0171-9335(04)70031-X. PMID 10826496.
• Walma T, Spronk CA, Tessari M, et al. (2002). "Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL". J. Mol. Biol. 316 (5): 1101–10. doi:10.1006/jmbi.2002.5402. hdl:2066/187660. PMID 11884147.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Omasu F, Ezura Y, Kajita M, et al. (2003). "Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women". J. Hum. Genet. 48 (7): 342–5. doi:10.1007/s10038-003-0035-1. PMID 12908099.
• Vallenius T, Scharm B, Vesikansa A, et al. (2004). "The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of alpha-actinin with F-actin". Exp. Cell Res. 293 (1): 117–28. doi:10.1016/j.yexcr.2003.09.004. PMID 14729062.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• van den Berk LC, van Ham MA, te Lindert MM, et al. (2005). "The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain". Mol. Biol. Rep. 31 (4): 203–15. doi:10.1007/s11033-005-1407-8. hdl:2381/23201. PMID 15663004. S2CID 21554968.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Schwartz LM, Woloshin S, Birkmeyer JD (2005). "How do elderly patients decide where to go for major surgery? Telephone interview survey". BMJ. 331 (7520): 821. doi:10.1136/bmj.38614.449016.DE. PMC 1246083. PMID 16192286.
• Boumber YA, Kondo Y, Chen X, et al. (2007). "RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis". Cancer Res. 67 (5): 1997–2005. doi:10.1158/0008-5472.CAN-06-3093. PMID 17332327.