// Workers AI · dad joke modeWhat did PDE4C say to its date? You're a differential equation to my heart.

PDE4C
Identifiers
Aliases	PDE4C, DPDE1, phosphodiesterase 4C, PDE21
External IDs	OMIM: 600128; MGI: 99556; GeneCards: PDE4C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QYM
Enzyme activity
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,248,200 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,203,835 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; tibial arteries; ; spleen; ; skeletal muscle tissue; ; gastrocnemius muscle; ; left ventricle; ; testicle; ; muscle layer of sigmoid colon; ; stromal cell of endometrium;
	Top expressed in
	renal cortex; ; proximal tubule; ; human kidney; ; right kidney; ; islet of Langerhans; ; hepatobiliary system; ; liver; ; muscle of thigh; ; muscle tissue; ; duodenum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; protein binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; 3',5'-cyclic-AMP phosphodiesterase activity;
Cellular component	cytosol; cell projection; extracellular space; cilium;
Biological process	cAMP catabolic process; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5143
	110385
	ENSG00000105650
	ENSMUSG00000031842
	Q08493
	Q3UEI1
NM_000923; NM_001098818; NM_001098819; NM_001330172; NM_001369701;
	NM_001395274
	NM_201607; NM_001310465
	NP_000914; NP_001092288; NP_001092289; NP_001317101; NP_001356630
	NP_001297394; NP_963901
	Wikidata
View/Edit Human	View/Edit Mouse

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.^[5]

Tissue localisation

PDE4C is predominantly found in peripheral tissues.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105650 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031842 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)".
↑ Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs". Current Pharmaceutical Design. 15 (14): 1688–1698. doi:10.2174/138161209788168092. PMID 19442182.

Engels P, Sullivan M, Müller T, Lübbert H (1995). "Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C)". FEBS Lett. 358 (3): 305–10. doi:10.1016/0014-5793(94)01460-I. PMID 7843419. S2CID 24276391.
Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat. Cell Mol. Genet. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369. S2CID 19182571.
Bolger G, Michaeli T, Martins T, et al. (1993). "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs". Mol. Cell. Biol. 13 (10): 6558–71. doi:10.1128/mcb.13.10.6558. PMC 364715. PMID 8413254.
Obernolte R, Ratzliff J, Baecker PA, et al. (1997). "Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis". Biochim. Biophys. Acta. 1353 (3): 287–97. doi:10.1016/s0167-4781(97)00080-8. PMID 9349724.
Owens RJ, Lumb S, Rees-Milton K, et al. (1998). "Molecular cloning and expression of a human phosphodiesterase 4C". Cell. Signal. 9 (8): 575–85. doi:10.1016/S0898-6568(97)00072-7. PMID 9429761.
Sullivan M, Olsen AS, Houslay MD (2000). "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND". Cell. Signal. 11 (10): 735–42. doi:10.1016/S0898-6568(99)00037-6. PMID 10574328.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
Pérez-Torres S, Miró X, Palacios JM, et al. (2001). "Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain". J. Chem. Neuroanat. 20 (3–4): 349–74. doi:10.1016/S0891-0618(00)00097-1. hdl:10261/112708. PMID 11207431. S2CID 25012736.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–4. doi:10.1126/science.1090100. PMID 14684825. S2CID 10007258.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

External links

Overview of all the structural information available in the PDB for UniProt: Q08493 (cAMP-specific 3',5'-cyclic phosphodiesterase 4C) at the PDBe-KB.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105650 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031842 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)".

[6] Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs". Current Pharmaceutical Design. 15 (14): 1688–1698. doi:10.2174/138161209788168092. PMID 19442182.

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// Workers AI · dad joke modeWhat did PDE4C say to its date? You're a differential equation to my heart.

Tissue localisation

References

Further reading

External links