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PCLAF
Identifiers
Aliases	PCLAF, L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF, KIAA0101, PCNA clamp associated factor
External IDs	OMIM: 610696; MGI: 1915276; GeneCards: PCLAF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D2G
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,387,687 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,810,548 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; embryo; ; ventricular zone; ; ganglionic eminence; ; bone marrow; ; gingival epithelium; ; thymus; ; hair follicle; ; bone marrow cell; ; oral cavity;
	Top expressed in
	yolk sac; ; tail of embryo; ; somite; ; embryo; ; ventricular zone; ; genital tubercle; ; embryo; ; maxillary prominence; ; mandibular prominence; ; atrium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chromatin binding; protein binding;
Cellular component	perinuclear region of cytoplasm; nucleus; nucleoplasm; cytoplasm; centrosome;
Biological process	DNA replication; translesion synthesis; response to UV; cellular response to DNA damage stimulus; regulation of cell cycle; DNA repair; centrosome cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9768
	68026
	ENSG00000166803
	ENSMUSG00000040204
	Q15004
	Q9CQX4
	NM_001029989; NM_014736
	NM_026515
	NP_001025160; NP_055551
	NP_080791
	Wikidata
View/Edit Human	View/Edit Mouse

PCNA-associated factor (also called “PCNA clamp associated factor”) is a protein that in humans is encoded by the PCLAF gene (previously KIAA0101).^[5]^[6]^[7] The PCLAF protein binds to PCNA and regulates DNA repair during DNA replication.^[8]

Interactions

PCLAF has been shown to interact with PCNA.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166803 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040204 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y (Jan 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. 20 (4): 484–9. doi:10.1038/sj.onc.1204113. PMID 11313979.
↑ Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts JS, Bowles J, Adolphe C, Simms LA, Young J, Walsh MD, Leggett B, Fowles LF, Wicking C (Jan 2006). "The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b". Experimental Cell Research. 312 (1): 73–85. doi:10.1016/j.yexcr.2005.09.020. PMID 16288740.
↑ "Entrez Gene: KIAA0101 KIAA0101".
↑ "Q15004 · PAF15_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-03.

Shi L, Zhang SL, Li K, Hong Y, Wang Q, Li Y, Guo J, Fan WH, Zhang L, Cheng J (Feb 2008). "NS5ATP9, a gene up-regulated by HCV NS5A protein". Cancer Letters. 259 (2): 192–7. doi:10.1016/j.canlet.2007.10.029. PMID 18068894.
Guo M, Li J, Wan D, Gu J (2006). "KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma". BMC Cancer. 6 109. doi:10.1186/1471-2407-6-109. PMC 1483895. PMID 16646990.
Mizutani K, Onda M, Asaka S, Akaishi J, Miyamoto S, Yoshida A, Nagahama M, Ito K, Emi M (May 2005). "Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma". Cancer. 103 (9): 1785–90. doi:10.1002/cncr.20988. PMID 15789362.
Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, Law CL, Wahl A, Carter P (Oct 2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166803 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040204 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11313979-5] 1 2 Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y (Jan 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. 20 (4): 484–9. doi:10.1038/sj.onc.1204113. PMID 11313979.

[pmid16288740-6] Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts JS, Bowles J, Adolphe C, Simms LA, Young J, Walsh MD, Leggett B, Fowles LF, Wicking C (Jan 2006). "The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b". Experimental Cell Research. 312 (1): 73–85. doi:10.1016/j.yexcr.2005.09.020. PMID 16288740.

[entrez-7] "Entrez Gene: KIAA0101 KIAA0101".

[8] "Q15004 · PAF15_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-03.

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Interactions

References

Further reading