// Workers AI · dad joke modeWhat did PABIR1 say to its date? You're a perfect match, I'm paired with you.

PABIR1
Identifiers
Aliases	PABIR1, C9orf42, family with sequence similarity 122A, PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1, FAM122A
External IDs	OMIM: 617249; MGI: 1915284; GeneCards: PABIR1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	68,785,566 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	24,454,720 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; pancreatic epithelial cell; ; tibialis anterior muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; right ventricle; ; popliteal artery; ; tibial arteries; ; retinal pigment epithelium;
	Top expressed in
	retinal pigment epithelium; ; Rostral migratory stream; ; secondary oocyte; ; zygote; ; Epithelium of choroid plexus; ; primary oocyte; ; internal carotid artery; ; islet of Langerhans; ; external carotid artery; ; ciliary body;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	116224
	68034
	ENSG00000187866
	ENSMUSG00000074922
	Q96E09
	Q9DB52
	NM_138333
	NM_026520
	NP_612206
	NP_080796
	Wikidata
View/Edit Human	View/Edit Mouse

PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 is a protein that in humans is encoded by the PABIR1 gene.^[5] The PABIR1 protein acts to promote cell growth and the progression of mitosis (specifically the G2/M checkpoint).^[5]^[6] It does this by inhibiting the protein phosphatase PP2A by binding to PPP2R2A and PPP2CA, and blocking their substrate binding site and active site respectively.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187866 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074922 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Family with sequence similarity 122A". Retrieved 2016-03-16.
1 2 "Q96E09 · PBIR1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-24.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187866 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074922 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: Family with sequence similarity 122A". Retrieved 2016-03-16.

[uniprot-6] 1 2 "Q96E09 · PBIR1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-24.

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// Workers AI · dad joke modeWhat did PABIR1 say to its date? You're a perfect match, I'm paired with you.

See also

References