Oscillibacter sp ER4
| Oscillibacter sp ER4 | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Bacillota |
| Class: | Clostridia |
| Order: | Eubacteriales |
| Family: | Oscillospiraceae |
| Genus: | Oscillibacter |
| Species: | O. sp. ER4 |
| Binomial name | |
| Oscillibacter sp. ER4 | |
Oscillibacter sp. ER4 is a species of bacteria in the gut microbiome.[1] This specific Oscillibacter species is poorly documented. It has been obtained from human gut isolate.[2]
O. sp. ER4 has been linked to improved immunotherapy outcomes:[3] a patients with a high abundance of O. sp. ER4 had a prolonged immunotherapy-related overall survival compared to patients with a low abundance.[3] Microbiome and immunotherapy responses are longer.[3] The bacterium is also possibly involved in ageing-related anorexia, although this cannot be confirmed until further research has been conducted.[1]
The bacterium is negatively correlated with triglyceride levels[4] and negatively associated with systolic blood pressure, driven by women.[5] O. sp. ER4 has been identified as a species of beneficial bacteria closely associated with the absence of subclinical atherosclerosis;[6] O. sp. ER4 is more abundant in healthy control groups than in atherosclerotic patients.[4]
Although linked to improved immunotherapy outcomes, the bacterium seems, interestingly, to have a negative influence on the immunotherapy for colorectal cancer and esophageal squamous cell carcinoma.[3]
A comparison of metagenome-assembled O. sp. ER4 genomes revealed a clade enriched in older individuals which was characterised by the depletion of genes related to biotin and amino acid metabolism.[1]
There is an inverse relationship between O. sp. ER4 and chronic liver histological damage[7] and the bacterium has been shown to decreased blood and stool cholesterol.[8]
References
[edit]- 1 2 3 Fu, Jingyuan; Zhang, Yue; Zhernakova, Daria; Gacesa, Ranko; Andreu-Sánchez, Sergio; Wu, Jiafei; Kurilshikov, Alexander; Wu, Jiqiu; Temba, Godfrey (2025-07-29). "Microbial Adaptation in Healthy Ageing: Insights from Age-associated Structural Variation in the Human Gut Microbiome". doi.org. doi:10.21203/rs.3.rs-5633858/v1. Retrieved 2026-08-22.
- ↑ Gophna, Uri; Konikoff, Tom; Nielsen, Henrik Bjørn (2017-02-03). "Oscillospira and related bacteria – From metagenomic species to metabolic features". Environmental Microbiology. 19 (3): 835–841. Bibcode:2017EnvMi..19..835G. doi:10.1111/1462-2920.13658. ISSN 1462-2912. PMID 28028921.
- 1 2 3 4 Jia, Keren; Chen, Yang; Dai, Die; Xie, Yi; Peng, Haoxin; Cao, Yanshuo; Zou, Hua; Qiu, Chuangzhao; Tan, Yan; Zhang, Xiaotian; Lu, Zhihao; Yin, Xiaochen; Peng, Zhi; Li, Jian; Shen, Lin (2026-01-12). "Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer". BMC Medicine. 24 (1) 79. doi:10.1186/s12916-025-04575-0. ISSN 1741-7015. PMC 12888622. PMID 41526899.
- 1 2 D'aiello, A; Morini, S; Biasucci, F; Brecciaroli, M; Filomia, S; Pedicino, D; Genuardi, L; Santucci, E; Tarquini, D; Proto, L; Grimaldi, M C; Santoliquido, A; Liuzzo, G; Severino, A (May 2025). "Gut microbiota and subclinical atherosclerosis: a new emerging perspective". European Journal of Preventive Cardiology. 32 (Supplement_1) zwaf236.196. doi:10.1093/eurjpc/zwaf236.196. ISSN 2047-4873.
- ↑ Virwani, Preeti Dinesh; Qian, Gordon; Cheung, Carman Nga-Man; Pijarnvanit, Tommy K.K.T.S.; Hsu, Matthew S.S.; Chow, Yick Hin; Tang, Lok Kan; Tse, Yiu-Hei; Xian, Jia-Wen; Lam, Shirley Sau-Wing; Lee, Crystal P.I.; Lo, Chelsea C.W.; Liu, Roxanna K.C.; Ho, Tsi Lok; Chow, Bak Yue (2026). "Associations between gut microbiome and 24-hour blood pressure variability: a cross-sectional study highlighting sex differences and potential therapeutic targets". Gut Microbiome. 7 e9. doi:10.1017/gmb.2026.10026. ISSN 2632-2897. PMC 13279954. PMID 42326837.
- ↑ D'aiello, A; Morini, S; Pedicino, D; Filomia, S; Brecciaroli, M; Grimaldi, M C; Genuardi, L; Santucci, E; Tarquini, D; Proto, L; Santoliquido, A; Segata, N; Severino, A; Liuzzo, G (November 2025). "Gut microbiota signatures in subclinical atherosclerosis: links to lipid metabolism and cardiovascular risk modulation". European Heart Journal. 46 (Supplement_1) ehaf784.3471. doi:10.1093/eurheartj/ehaf784.3471. ISSN 0195-668X.
- ↑ Wang, Fengjiao; Wu, Yechen; Ni, Jiali; Xie, Qianhan; Shen, Jian; Chen, Hui; Ma, Chengyu; Yao, Yuanyuan; Wang, Jinzhi; Xu, Lvwan; Xiang, Qiangqiang; Zhao, Yuxi; Chen, Yanfei; Li, Lanjuan (2025-08-05). Liu, Benjamin M. (ed.). "Gut microbiota links to histological damage in chronic HBV infection patients and aggravates fibrosis via fecal microbiota transplantation in mice". Microbiology Spectrum. 13 (8) e00764-25. doi:10.1128/spectrum.00764-25. ISSN 2165-0497. PMC 12323656. PMID 40642988.
- ↑ Li, Chenhao; Stražar, Martin; Mohamed, Ahmed M.T.; Pacheco, Julian A.; Walker, Rebecca L.; Lebar, Tina; Zhao, Shijie; Lockart, Julia; Dame, Andrea; Thurimella, Kumar; Jeanfavre, Sarah; Brown, Eric M.; Ang, Qi Yan; Berdy, Brittany; Sergio, Dallis (April 2024). "Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria". Cell. 187 (8): 1834–1852.e19. doi:10.1016/j.cell.2024.03.014. ISSN 0092-8674. PMC 11071153. PMID 38569543.