OTUD7B

OTUD7B
Identifiers
Aliases	OTUD7B, CEZANNE, ZA20D1, OTU deubiquitinase 7B
External IDs	OMIM: 611748; MGI: 2654703; HomoloGene: 10624; GeneCards: OTUD7B; OMA:OTUD7B - orthologs
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.4.19.12 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.2 Start 149,937,812 bp End 150,010,726 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.1 Start 96,011,839 bp End 96,068,446 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell internal globus pallidus sural nerve secondary oocyte tendon of biceps brachii corpus callosum inferior ganglion of vagus nerve C1 segment Skeletal muscle tissue of biceps brachii epithelium of colon Top expressed in blood retinal pigment epithelium sciatic nerve right lung lobe neural layer of retina spermatid lumbar subsegment of spinal cord spermatocyte triceps brachii muscle muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding cysteine-type peptidase activity zinc ion binding metal ion binding peptidase activity K63-linked polyubiquitin modification-dependent protein binding protein binding thiol-dependent deubiquitinase hydrolase activity Lys48-specific deubiquitinase activity Cellular component cytoplasm nucleus cytosol Biological process mucosal immune response negative regulation of protein localization to nucleus protein K48-linked deubiquitination protein deubiquitination involved in ubiquitin-dependent protein catabolic process immune system process negative regulation of transcription by RNA polymerase II negative regulation of I-kappaB kinase/NF-kappaB signaling proteolysis negative regulation of interleukin-8 production protein K63-linked deubiquitination immune response protein deubiquitination protein K11-linked deubiquitination adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56957 229603 Ensembl ENSG00000264522 ENSMUSG00000038495 UniProt Q6GQQ9 B2RUR8 RefSeq (mRNA) NM_020205 NM_001025613 NM_001025614 RefSeq (protein) NP_064590 NP_001020784 NP_001020785 Location (UCSC) Chr 1: 149.94 – 150.01 Mb Chr 3: 96.01 – 96.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

OTU domain-containing protein 7B is a protein that in humans is encoded by the OTUD7B gene.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Evans PC, Ovaa H, Hamon M, et al. (2004). "Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity". Biochem. J. 378 (Pt 3): 727–34. doi:10.1042/BJ20031377. PMC 1224040. PMID 14748687.
• Evans PC, Smith TS, Lai MJ, et al. (2003). "A novel type of deubiquitinating enzyme". Journal of Biological Chemistry. 278 (25): 23180–6. doi:10.1074/jbc.M301863200. PMID 12682062.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Heyninck K, Beyaert R (1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Letters. 442 (2–3): 147–50. doi:10.1016/S0014-5793(98)01645-7. PMID 9928991.