// Workers AI · dad joke modeWhat did ORMDL1 gene say? I'm in a cell-abration.

ORMDL1
Identifiers
Aliases	ORMDL1, ORMDL sphingolipid biosynthesis regulator 1
External IDs	OMIM: 610073; MGI: 2181669; HomoloGene: 41135; GeneCards: ORMDL1; OMA:ORMDL1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q32.2 Start 189,770,267 bp End 189,784,364 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C1.1 Start 53,336,254 bp End 53,349,468 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas granulocyte spleen monocyte anterior pituitary gastric mucosa right lung mucosa of ileum gallbladder right uterine tube Top expressed in transitional epithelium of urinary bladder medial ganglionic eminence endocardial cushion abdominal wall left lobe of liver Paneth cell migratory enteric neural crest cell primitive streak atrioventricular junction atrioventricular valve More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 94101 227102 Ensembl ENSG00000128699 ENSMUSG00000026097 UniProt Q9P0S3 Q921I0 RefSeq (mRNA) NM_001128150 NM_016467 NM_145517 RefSeq (protein) NP_001121622 NP_057551 NP_001358313 NP_001358314 NP_001358315 NP_001358316 NP_001358317 NP_663492 Location (UCSC) Chr 2: 189.77 – 189.78 Mb Chr 1: 53.34 – 53.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

ORMDL sphingolipid biosynthesis regulator 1 is a protein that in humans is encoded by the ORMDL1 gene.

Further reading

• Araki W, Takahashi-Sasaki N, Chui DH, Saito S, Takeda K, Shirotani K, Takahashi K, Murayama KS, Kametani F, Shiraishi H, Komano H, Tabira T (2008). "A family of membrane proteins associated with presenilin expression and gamma-secretase function". FASEB J. 22 (3): 819–27. doi:10.1096/fj.07-9072com. PMID 17928364. S2CID 3855661.
• Siow DL, Wattenberg BW (2012). "Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis". J. Biol. Chem. 287 (48): 40198–204. doi:10.1074/jbc.C112.404012. PMC 3504734. PMID 23066021.
• Gupta SD, Gable K, Alexaki A, Chandris P, Proia RL, Dunn TM, Harmon JM (2015). "Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells". J. Biol. Chem. 290 (1): 90–8. doi:10.1074/jbc.M114.588236. PMC 4281770. PMID 25395622.