// Workers AI · dad joke modeWhat did ONECUT1 say to its date? You're a cut above.

ONECUT1
Identifiers
Aliases	ONECUT1, HNF-6, HNF6, HNF6A, one cut homeobox 1
External IDs	OMIM: 604164; MGI: 1196423; GeneCards: ONECUT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S7E
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.3 Start 52,755,053 bp End 52,791,078 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 D|9 41.93 cM Start 74,769,203 bp End 74,799,063 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right lobe of liver gallbladder testicle islet of Langerhans buccal mucosa cell gonad right testis left testis granulocyte Top expressed in female urethra wall of urinary bladder mucosa of urinary bladder urothelium transitional epithelium of urinary bladder liver stroma of kidney epithelium of female urethra greater petrosal nerve secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process Notch signaling pathway epithelial cell development cell differentiation cell fate commitment endoderm development regulation of transcription, DNA-templated positive regulation of cell migration regulation of transcription by RNA polymerase II anatomical structure morphogenesis negative regulation of transforming growth factor beta receptor signaling pathway spleen development transcription by RNA polymerase II transcription, DNA-templated regulation of cell-matrix adhesion glucose metabolic process pancreas development liver development B cell differentiation positive regulation of transcription by RNA polymerase II organism system development endocrine pancreas development cilium assembly Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 3175 15379 Ensembl ENSG00000169856 ENSMUSG00000043013 UniProt Q9UBC0 O08755 RefSeq (mRNA) NM_004498 NM_008262 RefSeq (protein) NP_004489 NP_032288 Location (UCSC) Chr 15: 52.76 – 52.79 Mb Chr 9: 74.77 – 74.8 Mb PubMed search
Wikidata
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One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene.

Structure

This gene encodes a member of the Cut homeobox family of transcription factors.

Function

Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. It is important for the differentiation of pancreas endocrine cells.

Clinical significance

Mutations in ONECUT1 are involved in juvenile diabetes. Alternative splicing results in multiple transcript variants.

Further reading

• Rausa FM, Tan Y, Costa RH (2003). "Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding". Molecular and Cellular Biology. 23 (2): 437–449. doi:10.1128/mcb.23.2.437-449.2003. PMC 151533. PMID 12509444.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.