OAS3

This article is about the enzyme. For the computer programming specification, see OpenAPI Specification.

OAS3
Identifiers
Aliases	OAS3, p100, p100OAS, 2'-5'-oligoadenylate synthetase 3
External IDs	OMIM: 603351; MGI: 2180850; HomoloGene: 4510; GeneCards: OAS3; OMA:OAS3 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4S3N
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.7.84 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.13 Start 112,938,051 bp End 112,976,460 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 F|5 60.64 cM Start 120,891,163 bp End 120,915,726 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte decidua gallbladder apex of heart mucosa of esophagus appendix bone marrow cell oral cavity epithelium of colon Top expressed in granulocyte blood mucous cell of stomach intestinal villus jejunum bone marrow stroma of bone marrow zygote thymus spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding nucleotidyltransferase activity metal ion binding 2'-5'-oligoadenylate synthetase activity protein binding RNA binding double-stranded RNA binding ATP binding Cellular component cytoplasm intracellular membrane-bounded organelle plasma membrane nucleoplasm nucleus extracellular space cytosol Biological process regulation of ribonuclease activity immune system process interferon-gamma-mediated signaling pathway response to virus negative regulation of viral genome replication defense response to virus type I interferon signaling pathway immune response innate immune response nucleobase-containing compound metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4940 246727 Ensembl ENSG00000111331 ENSMUSG00000032661 UniProt Q9Y6K5 Q8VI93 RefSeq (mRNA) NM_006187 NM_145226 RefSeq (protein) NP_006178 NP_660261 Location (UCSC) Chr 12: 112.94 – 112.98 Mb Chr 5: 120.89 – 120.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of ATP. These oligomers activate latent RNase L, leading to degradation of both viral and endogenous RNA. This enzyme family plays a significant role in the inhibition of cellular protein synthesis in response to viral infection.

Further reading

• Hovanessian AG, Justesen J (2007). "The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation". Biochimie. 89 (6–7): 779–88. doi:10.1016/j.biochi.2007.02.003. PMID 17408844.
• Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
• Hovanessian AG, Laurent AG, Chebath J, et al. (1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies". EMBO J. 6 (5): 1273–80. doi:10.1002/j.1460-2075.1987.tb02364.x. PMC 553929. PMID 2440675.
• Marié I, Blanco J, Rebouillat D, Hovanessian AG (1997). "69-kDa and 100-kDa isoforms of interferon-induced (2'-5')oligoadenylate synthetase exhibit differential catalytic parameters". Eur. J. Biochem. 248 (2): 558–66. doi:10.1111/j.1432-1033.1997.t01-1-00558.x. PMID 9346316.
• Rebouillat D, Hovnanian A, Marié I, Hovanessian AG (1999). "The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains". J. Biol. Chem. 274 (3): 1557–65. doi:10.1074/jbc.274.3.1557. PMID 9880533.
• Rebouillat D, Hovnanian A, David G, et al. (2001). "Characterization of the gene encoding the 100-kDa form of human 2',5' oligoadenylate synthetase". Genomics. 70 (2): 232–40. doi:10.1006/geno.2000.6382. PMID 11112351.
• Ito M, Shichijo S, Tsuda N, et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells". Cancer Res. 61 (5): 2038–46. PMID 11280764.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. Bibcode:2006Natur.440..346S. doi:10.1038/nature04569. PMID 16541075.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9Y6K5 (2'-5'-oligoadenylate synthase 3) at the PDBe-KB.