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// Workers AI · dad joke modeIs Nafithromycin a good antibiotic? It's a macro-lide above the rest.

From Wikipedia, the free encyclopedia

Nafithromycin
Clinical data
Other namesWCK-4873
ATC code
Identifiers
  • (1S,2R,5R,7R,8R,9R,11R,13R,14S,15R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,6,12,16-tetraoxo-N'-[(1S)-1-(5-pyridin-2-yl-1,3,4-thiadiazol-2-yl)ethoxy]-3,17-dioxabicyclo[12.3.0]heptadecane-15-carboximidamide
CAS Number
PubChem CID
UNII
KEGG
Chemical and physical data
FormulaC42H62N6O11S
Molar mass859.05 g·mol−1
3D model (JSmol)
  • CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)[C@@H](C(=O)O2)/C(=N/O[C@@H](C)C4=NN=C(S4)C5=CC=CC=N5)/N)C
  • InChI=1S/C42H62N6O11S/c1-13-28-42(9)30(29(39(53)58-42)35(43)47-59-25(7)36-45-46-37(60-36)26-16-14-15-17-44-26)22(4)31(49)20(2)19-41(8,54-12)34(23(5)32(50)24(6)38(52)56-28)57-40-33(51)27(48(10)11)18-21(3)55-40/h14-17,20-25,27-30,33-34,40,51H,13,18-19H2,1-12H3,(H2,43,47)/t20-,21-,22-,23+,24-,25+,27+,28-,29-,30+,33-,34-,40+,41-,42-/m1/s1
  • Key:RLFCSBSRGRJFRO-QAOQTAGDSA-N

Nafithromycin is an experimental antibiotic medication for the treatment of pneumonia.[1][2]

References

[edit]
  1. Iwanowski P, Bhatia A, Gupta M, Patel A, Chavan R, Yeole R, et al. (September 2019). "Safety, tolerability and pharmacokinetics of oral nafithromycin (WCK4873) after single or multiple doses and effects of food on single-dose bioavailability in healthy adult subjects". Antimicrobial Agents and Chemotherapy. 63 (12). doi:10.1128/AAC.01253-19. PMC 6879255. PMID 31591119.
  2. Sellarès-Nadal J, Burgos J, Falcó V, Almirante B (2020). "Investigational and Experimental Drugs for Community-Acquired Pneumonia: the Current Evidence". Journal of Experimental Pharmacology. 12: 529–538. doi:10.2147/JEP.S259286. PMC 7682597. PMID 33239925.