NUDT3

NUDT3
Identifiers
Aliases	NUDT3, DIPP, DIPP-1, DIPP1, nudix hydrolase 3
External IDs	OMIM: 609228; MGI: 1928484; HomoloGene: 31400; GeneCards: NUDT3; OMA:NUDT3 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FVV, 2Q9P
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	34,392,669 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,842,469 bp
RNA expression pattern
	Top expressed in
	dorsal motor nucleus of vagus nerve; ; inferior olivary nucleus; ; postcentral gyrus; ; Brodmann area 46; ; Brodmann area 10; ; middle frontal gyrus; ; Region I of hippocampus proper; ; lateral nuclear group of thalamus; ; external globus pallidus; ; entorhinal cortex;
	Top expressed in
	neural layer of retina; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; central gray substance of midbrain; ; cingulate gyrus; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity; inositol diphosphate tetrakisphosphate diphosphatase activity; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; hydrolase activity; diphosphoinositol-polyphosphate diphosphatase activity; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity; metal ion binding; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; magnesium ion binding; inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity; inositol diphosphate pentakisphosphate diphosphatase activity; inositol bisdiphosphate tetrakisphosphate diphosphatase activity; endopolyphosphatase activity; bis(5'-adenosyl)-hexaphosphatase activity; bis(5'-adenosyl)-pentaphosphatase activity; m7G(5')pppN diphosphatase activity;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	cell-cell signaling; diadenosine polyphosphate catabolic process; inositol phosphate metabolic process; diphosphoinositol polyphosphate catabolic process; diadenosine pentaphosphate catabolic process; diadenosine hexaphosphate catabolic process; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process; diphosphoinositol polyphosphate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11165
	56409
	ENSG00000272325
	ENSMUSG00000024213
	O95989
	Q9JI46
	NM_006703
	NM_001291046; NM_019837
	NP_006694
	NP_001277975; NP_062811
	Wikidata
View/Edit Human	View/Edit Mouse

Diphosphoinositol polyphosphate phosphohydrolase 1 is an enzyme that in humans is encoded by the NUDT3 gene.^[5]^[6]

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998).[supplied by OMIM]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000272325 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024213 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (Jan 1999). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase". EMBO J. 17 (22): 6599–607. doi:10.1093/emboj/17.22.6599. PMC 1171006. PMID 9822604.
1 2 "Entrez Gene: NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3".

Safrany ST, Ingram SW, Cartwright JL, et al. (1999). "The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein". J. Biol. Chem. 274 (31): 21735–40. doi:10.1074/jbc.274.31.21735. PMID 10419486.
Yang X, Safrany ST, Shears SB (2000). "Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates". J. Biol. Chem. 274 (50): 35434–40. doi:10.1074/jbc.274.50.35434. PMID 10585413.
Fisher DI, Safrany ST, Strike P, et al. (2003). "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate". J. Biol. Chem. 277 (49): 47313–7. doi:10.1074/jbc.M209795200. PMID 12370170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000272325 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024213 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9822604-5] Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (Jan 1999). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase". EMBO J. 17 (22): 6599–607. doi:10.1093/emboj/17.22.6599. PMC 1171006. PMID 9822604.

[entrez-6] 1 2 "Entrez Gene: NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3".

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NUDT3

References

Further reading