NDC1

NDC1
Identifiers
Aliases	NDC1, NET3, TMEM48, NDC1 transmembrane nucleoporin
External IDs	OMIM: 610115; MGI: 1920037; GeneCards: NDC1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	53,838,463 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	107,273,543 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; ventricular zone; ; tibia; ; gingival epithelium; ; epithelium of nasopharynx; ; mucosa of colon; ; mucosa of sigmoid colon; ; germinal epithelium; ; testicle;
	Top expressed in
	tail of embryo; ; genital tubercle; ; primitive streak; ; cumulus cell; ; spermatocyte; ; epiblast; ; maxillary prominence; ; condyle; ; yolk sac; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of nuclear pore;
Cellular component	cytoplasm; integral component of membrane; nuclear membrane; nuclear envelope; membrane; plasma membrane; nuclear pore; actin cytoskeleton; nucleus; spindle pole body; nuclear pore transmembrane ring; host cell;
Biological process	mRNA transport; nuclear pore complex assembly; viral transcription; protein sumoylation; mitotic nuclear membrane disassembly; homologous chromosome pairing at meiosis; spermatogenesis; protein transport; regulation of cellular response to heat; viral process; mRNA export from nucleus; intracellular transport of virus; tRNA export from nucleus; spindle pole body duplication; regulation of gene silencing by miRNA; regulation of glycolytic process; transport; nuclear pore organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55706
	72787
	ENSG00000058804
	ENSMUSG00000028614
	Q9BTX1
	Q8VCB1
	NM_001168551; NM_018087
	NM_028355
	NP_001162023; NP_060557
	NP_082631
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoporin NDC1 is a protein that in humans is encoded by the TMEM48 gene.^[5]^[6]^[7] It anchors aladin to the nuclear pore complex.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000058804 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028614 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lau CK, Delmar VA, Forbes DJ (August 2006). "Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue". The Anatomical Record. Part a, Discoveries in Molecular, Cellular, and Evolutionary Biology. 288 (7): 681–694. doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818.
↑ Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L (September 2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638). New York, N.Y.: 1380–1382. Bibcode:2003Sci...301.1380S. doi:10.1126/science.1088176. PMID 12958361. S2CID 23832536.
↑ "Entrez Gene: TMEM48 transmembrane protein 48".
↑ Kind B, Koehler K, Lorenz M, Huebner A (December 2009). "The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope". Biochemical and Biophysical Research Communications. 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080. PMID 19782045.

Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Mansfeld J, Güttinger S, Hawryluk-Gara LA, Panté N, Mall M, Galy V, et al. (April 2006). "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells". Molecular Cell. 22 (1): 93–103. doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
Stavru F, Hülsmann BB, Spang A, Hartmann E, Cordes VC, Görlich D (May 2006). "NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes". The Journal of Cell Biology. 173 (4): 509–519. doi:10.1083/jcb.200601001. PMC 2063861. PMID 16702233.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000058804 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028614 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Lau_2006-5] Lau CK, Delmar VA, Forbes DJ (August 2006). "Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue". The Anatomical Record. Part a, Discoveries in Molecular, Cellular, and Evolutionary Biology. 288 (7): 681–694. doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818.

[Schirmer_2003-6] Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L (September 2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638). New York, N.Y.: 1380–1382. Bibcode:2003Sci...301.1380S. doi:10.1126/science.1088176. PMID 12958361. S2CID 23832536.

[entrez-7] "Entrez Gene: TMEM48 transmembrane protein 48".

[8] Kind B, Koehler K, Lorenz M, Huebner A (December 2009). "The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope". Biochemical and Biophysical Research Communications. 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080. PMID 19782045.

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NDC1

References

Further reading