NAPG

NAPG
Identifiers
Aliases	NAPG, GAMMASNAP, NSF attachment protein gamma
External IDs	OMIM: 603216; MGI: 104561; HomoloGene: 2838; GeneCards: NAPG; OMA:NAPG - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18p11.22 Start 10,525,905 bp End 10,552,764 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 E1 Start 63,110,902 bp End 63,132,521 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pons pars compacta Brodmann area 23 islet of Langerhans C1 segment lateral nuclear group of thalamus middle temporal gyrus dorsolateral prefrontal cortex Brodmann area 9 Top expressed in subiculum pontine nuclei piriform cortex central gray substance of midbrain medial dorsal nucleus primary motor cortex inferior colliculi subdivision of hippocampus Region I of hippocampus proper habenula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function syntaxin binding protein binding soluble NSF attachment protein activity Cellular component myelin sheath lysosomal membrane SNARE complex extracellular exosome membrane mitochondrion vacuolar membrane synapse Biological process protein transport protein stabilization membrane fusion intracellular protein transport intra-Golgi vesicle-mediated transport vesicle-mediated transport transport protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8774 108123 Ensembl ENSG00000134265 ENSMUSG00000024581 UniProt Q99747 Q9CWZ7 RefSeq (mRNA) NM_003826 NM_028017 RefSeq (protein) NP_003817 NP_082293 Location (UCSC) Chr 18: 10.53 – 10.55 Mb Chr 18: 63.11 – 63.13 Mb PubMed search
Wikidata
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Gamma-soluble NSF attachment protein is a SNAP protein that in humans is encoded by the NAPG gene.

Function

NSF and SNAPs (NSF attachment proteins) are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.

Further reading

• Wilson DW, Whiteheart SW, Wiedmann M, et al. (1992). "A multisubunit particle implicated in membrane fusion". J. Cell Biol. 117 (3): 531–8. doi:10.1083/jcb.117.3.531. PMC 2289450. PMID 1315316.
• Whiteheart SW, Brunner M, Wilson DW, et al. (1992). "Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes". J. Biol. Chem. 267 (17): 12239–43. doi:10.1016/S0021-9258(19)49830-X. PMID 1601890.
• Whiteheart SW, Griff IC, Brunner M, et al. (1993). "SNAP family of NSF attachment proteins includes a brain-specific isoform". Nature. 362 (6418): 353–5. Bibcode:1993Natur.362..353W. doi:10.1038/362353a0. PMID 8455721. S2CID 4341471.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Mastick CC, Falick AL (1997). "Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes". Endocrinology. 138 (6): 2391–7. doi:10.1210/endo.138.6.5166. PMID 9165027.
• Subramaniam VN, Loh E, Horstmann H, et al. (2000). "Preferential association of syntaxin 8 with the early endosome" (PDF). J. Cell Sci. 113 (6): 997–1008. doi:10.1242/jcs.113.6.997. PMID 10683148.
• Chen D, Xu W, He P, et al. (2001). "Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria". J. Biol. Chem. 276 (16): 13127–35. doi:10.1074/jbc.M009424200. PMID 11278501.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tani K, Shibata M, Kawase K, et al. (2003). "Mapping of functional domains of gamma-SNAP". J. Biol. Chem. 278 (15): 13531–8. doi:10.1074/jbc.M213205200. PMID 12554740.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.