// Workers AI · dad joke modeWhat did Musashi-1 say to its clone? "You're a cut above.

MSI1
Identifiers
Aliases	MSI1, musashi RNA binding protein 1
External IDs	OMIM: 603328; MGI: 107376; GeneCards: MSI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UAW, 2MSS, 2MST, 2RS2
Gene location (Human)
Chr.	Chromosome 12 (human)
End	120,369,164 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	115,593,757 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; frontal pole; ; left testis; ; right testis; ; anterior pituitary; ; islet of Langerhans; ; amygdala; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; molar; ; epithelium of lens; ; Rostral migratory stream; ; ganglionic eminence; ; tail of embryo; ; habenula; ; epiblast; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	single-stranded RNA binding; nucleic acid binding; poly(U) RNA binding; identical protein binding; RNA binding;
Cellular component	cytoplasm; polysome; nucleus; ribonucleoprotein complex;
Biological process	nervous system development;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4440
	17690
	ENSG00000135097
	ENSMUSG00000054256
	O43347
	Q61474
	NM_002442
	NM_008629; NM_001376960; NM_001376961; NM_001376962; NM_001376963
	NP_002433
	NP_032655; NP_001363889; NP_001363890; NP_001363891; NP_001363892
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein Musashi homolog 1 also known as Musashi-1 is a protein that in humans is encoded by the MSI1 gene.^[5]^[6]

Function

This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA binding protein that is involved in post-transcriptional gene editing. It is a stem cell marker that controls the balance between self-renewal and terminal differentiation.^[7]^[6]

Clinical significance

Over expression of this gene is associated with the grade of the malignancy and proliferative activity in gliomas and melanomas.^[7] An increased expression of MSI1 protein is observed in endometriosis and endometrial carcinoma^[8] siRNA-mediated inhibition of MSI expression in endometrial carcinoma cells induces apoptosis and inhibits cell proliferation by affecting the Notch signaling pathway^[9]

MSI1 is highly expressed in neural progenitor cells and is required for normal development of the brain. A mutation in these gene is responsible for autosomal recessive primary microcephaly. MSI1 also interacts with the Zika virus genome and may explain why these cells are highly susceptible to Zika virus infection.^[10]^[11]

Name

The musashi (msi) mutant of Drosophila melanogaster, in which a homolog of the human MSI1 gene was discovered first, is characterized by formation of macrochaetes with double shafts.^[12] For this reason, the mutant and the corresponding gene and protein were named after Miyamoto Musashi who developed a double-bladed style of swordsmanship.^[12]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135097 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054256 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Good P, Yoda A, Sakakibara S, Yamamoto A, Imai T, Sawa H, et al. (September 1998). "The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells". Genomics. 52 (3): 382–384. doi:10.1006/geno.1998.5456. PMID 9790759.
1 2 "Entrez Gene: MSI1 musashi homolog 1 (Drosophila)".
1 2 Glazer RI, Vo DT, Penalva LO (2012). "Musashi1: an RBP with versatile functions in normal and cancer stem cells". Frontiers in Bioscience. 17 (1): 54–64. doi:10.2741/3915. PMID 22201732.
↑ Götte M, Wolf M, Staebler A, Buchweitz O, Kelsch R, Schüring AN, et al. (July 2008). "Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma". The Journal of Pathology. 215 (3): 317–329. doi:10.1002/path.2364. PMID 18473332. S2CID 206323361.
↑ Götte M, Greve B, Kelsch R, Müller-Uthoff H, Weiss K, Kharabi Masouleh B, et al. (October 2011). "The adult stem cell marker Musashi-1 modulates endometrial carcinoma cell cycle progression and apoptosis via Notch-1 and p21WAF1/CIP1". International Journal of Cancer. 129 (8): 2042–2049. doi:10.1002/ijc.25856. PMID 21165952. S2CID 35338227.
↑ Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, et al. (2017). "Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication". Science. 357 (6346). New York, N.Y.: 83–88. Bibcode:2017Sci...357...83C. doi:10.1126/science.aam9243. PMC 5798584. PMID 28572454.
↑ Griffin DE (2017). "Why are neurons susceptible to Zika virus?". Science. 357 (6346). New York, N.Y.: 33–34. Bibcode:2017Sci...357...33G. doi:10.1126/science.aan8626. PMID 28684491.
1 2 Nakamura M, Okano H, Blendy JA, Montell C (July 1994). "Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development". Neuron. 13 (1): 67–81. doi:10.1016/0896-6273(94)90460-X. PMID 8043282.

Okano H, Imai T, Okabe M (April 2002). "Musashi: a translational regulator of cell fate". Journal of Cell Science. 115 (Pt 7): 1355–1359. doi:10.1242/jcs.115.7.1355. PMID 11896183.
Toda M, Iizuka Y, Yu W, Imai T, Ikeda E, Yoshida K, et al. (April 2001). "Expression of the neural RNA-binding protein Musashi1 in human gliomas". Glia. 34 (1): 1–7. doi:10.1002/glia.1034. PMID 11284014. S2CID 24208393.
Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, et al. (June 2001). "The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA". Molecular and Cellular Biology. 21 (12): 3888–3900. doi:10.1128/MCB.21.12.3888-3900.2001. PMC 87052. PMID 11359897.
Sakakibara S, Nakamura Y, Satoh H, Okano H (October 2001). "Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS". The Journal of Neuroscience. 21 (20): 8091–8107. doi:10.1523/JNEUROSCI.21-20-08091.2001. PMC 6763847. PMID 11588182.
Kanemura Y, Mori K, Sakakibara S, Fujikawa H, Hayashi H, Nakano A, et al. (September 2001). "Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity". Differentiation; Research in Biological Diversity. 68 (2–3): 141–152. doi:10.1046/j.1432-0436.2001.680208.x. PMID 11686236.
Kanemura Y, Sakakibara S, Okano H (2002). "Identification of Musashi1-positive cells in human normal and neoplastic neuroepithelial tissues by immunohistochemical methods". Neural Stem Cells. Methods in Molecular Biology. Vol. 198. pp. 273–281. doi:10.1385/1-59259-186-8:273. ISBN 1-59259-186-8. PMID 11951628.
Shu HJ, Saito T, Watanabe H, Ito JI, Takeda H, Okano H, et al. (April 2002). "Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines". Biochemical and Biophysical Research Communications. 293 (1): 150–154. doi:10.1016/S0006-291X(02)00175-4. PMID 12054577.
Miyanoiri Y, Kobayashi H, Imai T, Watanabe M, Nagata T, Uesugi S, et al. (October 2003). "Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics". The Journal of Biological Chemistry. 278 (42): 41309–41315. doi:10.1074/jbc.M306210200. PMID 12907678.
Nishimura S, Wakabayashi N, Toyoda K, Kashima K, Mitsufuji S (August 2003). "Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium". Digestive Diseases and Sciences. 48 (8): 1523–1529. doi:10.1023/A:1024763723240. PMID 12924647. S2CID 27912813.
Lovell MA, Markesbery WR (August 2005). "Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease". Journal of Neuropathology and Experimental Neurology. 64 (8): 675–680. doi:10.1097/01.jnen.0000173891.17176.5b. PMID 16106215. S2CID 16906563.
Battelli C, Nikopoulos GN, Mitchell JG, Verdi JM (January 2006). "The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1". Molecular and Cellular Neurosciences. 31 (1): 85–96. doi:10.1016/j.mcn.2005.09.003. PMID 16214366. S2CID 11496642.
Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, et al. (October 2006). "Musashi1 antigen expression in human fetal germinal matrix development". Experimental Neurology. 201 (2): 515–518. doi:10.1016/j.expneurol.2006.04.023. PMID 16777095. S2CID 26877499.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135097 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054256 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Good_1998-5] Good P, Yoda A, Sakakibara S, Yamamoto A, Imai T, Sawa H, et al. (September 1998). "The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells". Genomics. 52 (3): 382–384. doi:10.1006/geno.1998.5456. PMID 9790759.

[entrez-6] 1 2 "Entrez Gene: MSI1 musashi homolog 1 (Drosophila)".

[Glazer_2012-7] 1 2 Glazer RI, Vo DT, Penalva LO (2012). "Musashi1: an RBP with versatile functions in normal and cancer stem cells". Frontiers in Bioscience. 17 (1): 54–64. doi:10.2741/3915. PMID 22201732.

[8] Götte M, Wolf M, Staebler A, Buchweitz O, Kelsch R, Schüring AN, et al. (July 2008). "Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma". The Journal of Pathology. 215 (3): 317–329. doi:10.1002/path.2364. PMID 18473332. S2CID 206323361.

[9] Götte M, Greve B, Kelsch R, Müller-Uthoff H, Weiss K, Kharabi Masouleh B, et al. (October 2011). "The adult stem cell marker Musashi-1 modulates endometrial carcinoma cell cycle progression and apoptosis via Notch-1 and p21WAF1/CIP1". International Journal of Cancer. 129 (8): 2042–2049. doi:10.1002/ijc.25856. PMID 21165952. S2CID 35338227.

[Chavali_2017-10] Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, et al. (2017). "Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication". Science. 357 (6346). New York, N.Y.: 83–88. Bibcode:2017Sci...357...83C. doi:10.1126/science.aam9243. PMC 5798584. PMID 28572454.

[Griffin_2017-11] Griffin DE (2017). "Why are neurons susceptible to Zika virus?". Science. 357 (6346). New York, N.Y.: 33–34. Bibcode:2017Sci...357...33G. doi:10.1126/science.aan8626. PMID 28684491.

[Nakamura_1994-12] 1 2 Nakamura M, Okano H, Blendy JA, Montell C (July 1994). "Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development". Neuron. 13 (1): 67–81. doi:10.1016/0896-6273(94)90460-X. PMID 8043282.

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// Workers AI · dad joke modeWhat did Musashi-1 say to its clone? "You're a cut above.

Function

Clinical significance

Name

See also

References

Further reading