// Workers AI · dad joke modeWhat did Midaflur say to its date? You're the flour of my life.

Midaflur
Clinical data
ATC code	None;
Identifiers
	IUPAC name 2,2,5,5-Tetrakis(trifluoromethyl)-2,5-dihydro-1H-imidazol-4-amine;
CAS Number	23757-42-8;
PubChem CID	32068;
ChemSpider	29737;
UNII	840CTL676L;
KEGG	D05027;
ChEMBL	ChEMBL2104707;
CompTox Dashboard (EPA)	DTXSID50178425;
Chemical and physical data
Formula	C7H3F12N3
Molar mass	357.103 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1(=NC(NC1(C(F)(F)F)C(F)(F)F)(C(F)(F)F)C(F)(F)F)N;
	InChI InChI=1S/C7H3F12N3/c8-4(9,10)2(5(11,12)13)1(20)21-3(22-2,6(14,15)16)7(17,18)19/h22H,(H2,20,21); Key:KYWMWUUMCDZISK-UHFFFAOYSA-N;

Midaflur (INN; EXP 338) is an extremely stable 3-imidazoline derivative with central skeletal muscle relaxant and sedative properties in humans^[1] and other species of mammals, exhibiting consistently high oral bioavailability and a long duration of action. While its pharmacodynamics remain poorly understood, midaflur resembles meprobamate and pentobarbital in terms of observed effects while being considerably more potent.^[2]

References

↑ Levine IM, Jossmann PB, Friend DG, DeAngelis V (1967). "Effect of 5-imino-2,2,4,4-tetrakis (trifluoromethyl) imidazolidine (EXP 338) on spasticity: A quantitative evaluation". Clinical Pharmacology and Therapeutics. 9 (4): 448–55. doi:10.1002/cpt196894448. PMID 4871898. S2CID 39263140.
↑ Clark R, Lynes TE, Price WA, Smith DH, Woodward JK, Marvel JP, Vernier VG (April 1971). "The pharmacology and toxicology of midaflur". Toxicology and Applied Pharmacology. 18 (4): 917–43. Bibcode:1971ToxAP..18..917C. doi:10.1016/0041-008x(71)90239-0. PMID 5570243.

[1] Levine IM, Jossmann PB, Friend DG, DeAngelis V (1967). "Effect of 5-imino-2,2,4,4-tetrakis (trifluoromethyl) imidazolidine (EXP 338) on spasticity: A quantitative evaluation". Clinical Pharmacology and Therapeutics. 9 (4): 448–55. doi:10.1002/cpt196894448. PMID 4871898. S2CID 39263140.

[2] Clark R, Lynes TE, Price WA, Smith DH, Woodward JK, Marvel JP, Vernier VG (April 1971). "The pharmacology and toxicology of midaflur". Toxicology and Applied Pharmacology. 18 (4): 917–43. Bibcode:1971ToxAP..18..917C. doi:10.1016/0041-008x(71)90239-0. PMID 5570243.

[1]

[2]

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// Workers AI · dad joke modeWhat did Midaflur say to its date? You're the flour of my life.

See also

References