Mazisotine

Mazisotine
Clinical data
Other names	LY3556050, CNTX-0290
Identifiers
	IUPAC name (1S,5R)-N-[2-methyl-1-[(3-methyl-2-pyridinyl)oxy]propan-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxamide;
CAS Number	1638588-92-7;
PubChem CID	86294067;
ChemSpider	77005706;
UNII	D3M32WP3MH;
ChEMBL	ChEMBL5874446;
Chemical and physical data
Formula	C16H23N3O2
Molar mass	289.379 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(COc1ncccc1C)NC(=O)[C@H]1[C@@H]2CNC[C@H]12;
	InChI InChI=1S/C16H23N3O2/c1-10-5-4-6-18-15(10)21-9-16(2,3)19-14(20)13-11-7-17-8-12(11)13/h4-6,11-13,17H,7-9H2,1-3H3,(H,19,20)/t11-,12+,13?; Key:PCINBSQTEDBZDB-FUNVUKJBSA-N;

Mazisotine (LY3556050, CNTX-0290) is a chemical compound which acts as an agonist at somatostatin receptor 4. It has analgesic effects and has been researched for the treatment of pain associated with arthritis and neuropathic pain. It was not pursued for human medical use following disappointing results in Phase II clinical trials, but continues to be used in scientific research.^[1]^[2]

References

↑ Stevens R, Corradini L, Doods H (April 2019). "Preclinical Evaluation of Human Somatostatin Receptor 4 (hSSTR4) Agonist CNTX-0290 for Mixed Pain Conditions". The Journal of Pain. 20 (4): S73. doi:10.1016/j.jpain.2019.02.092.
↑ Nguyen TH, Saito T, Chang W, Navarro A, Davies HM (March 2026). "Diastereoselective Cyclopropanation with Secondary Diazoacetamides to Access endo-Azabicyclo[3.1.0]hexane-6-carboxamides". Organic Letters. 28 (9): 3063–3067. doi:10.1021/acs.orglett.6c00392. PMC 12973298. PMID 41729728.

[1] Stevens R, Corradini L, Doods H (April 2019). "Preclinical Evaluation of Human Somatostatin Receptor 4 (hSSTR4) Agonist CNTX-0290 for Mixed Pain Conditions". The Journal of Pain. 20 (4): S73. doi:10.1016/j.jpain.2019.02.092.

[Nguyen_2026-2] Nguyen TH, Saito T, Chang W, Navarro A, Davies HM (March 2026). "Diastereoselective Cyclopropanation with Secondary Diazoacetamides to Access endo-Azabicyclo[3.1.0]hexane-6-carboxamides". Organic Letters. 28 (9): 3063–3067. doi:10.1021/acs.orglett.6c00392. PMC 12973298. PMID 41729728.

[1]

[2]

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Mazisotine

See also

References