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MRPS22
Identifiers
Aliases	MRPS22, C3orf5, COXPD5, GIBT, MRP-S22, RPMS22, GK002, mitochondrial ribosomal protein S22, ODG7
External IDs	OMIM: 605810; MGI: 1928137; HomoloGene: 57030; GeneCards: MRPS22; OMA:MRPS22 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Gene location (Human) Chr. Chromosome 3 (human) Band 3q23 Start 139,005,806 bp End 139,360,497 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E3.3 Start 98,470,783 bp End 98,483,713 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex gonad Achilles tendon tibialis anterior muscle left adrenal gland endothelial cell myocardium of left ventricle deltoid muscle left adrenal cortex Top expressed in primary oocyte medial ganglionic eminence maxillary prominence mandibular prominence abdominal wall renal corpuscle facial motor nucleus medullary collecting duct ureter atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrion mitochondrial small ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56945 64655 Ensembl ENSG00000175110 ENSMUSG00000032459 UniProt P82650 Q9CXW2 RefSeq (mRNA) NM_020191 NM_001363857 NM_001363893 NM_025485 RefSeq (protein) NP_064576 NP_001350786 NP_001350822 NP_079761 Location (UCSC) Chr 3: 139.01 – 139.36 Mb Chr 9: 98.47 – 98.48 Mb PubMed search
Wikidata
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28S ribosomal protein S22, mitochondrial is a protein that in humans is encoded by the MRPS22 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq.

Further reading

• Koc EC, Burkhart W, Blackburn K, et al. (2000). "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins". J. Biol. Chem. 275 (42): 32585–91. doi:10.1074/jbc.M003596200. PMID 10938081.
• Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. CiteSeerX 10.1.1.501.8919. doi:10.1074/jbc.M100727200. PMID 11279123.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Crisponi L, Uda M, Deiana M, et al. (2004). "FOXL2 inactivation by a translocation 171 kb away: analysis of 500 kb of chromosome 3 for candidate long-range regulatory sequences". Genomics. 83 (5): 757–64. doi:10.1016/j.ygeno.2003.11.010. PMID 15081106.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. Bibcode:2005BBRC..337.1308G. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.