// Workers AI · dad joke modeWhat did MIB1 say to the alien? You're "men" in blacklisted.

MIB1
Identifiers
Aliases	MIB1, DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6, mindbomb E3 ubiquitin protein ligase 1, MIB E3 ubiquitin protein ligase 1
External IDs	OMIM: 608677; MGI: 2443157; HomoloGene: 10810; GeneCards: MIB1; OMA:MIB1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4TSE, 4XI6, 4XI7, 4XIB
Enzyme activity
Gene location (Human)
Chr.	Chromosome 18 (human)
End	21,870,953 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	10,818,704 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; tibia; ; nipple; ; caput epididymis; ; parietal pleura; ; tail of epididymis; ; cartilage tissue; ; corpus callosum; ; visceral pleura; ; secondary oocyte;
	Top expressed in
	spermatid; ; parotid gland; ; ciliary body; ; ureter; ; dentate gyrus of hippocampal formation granule cell; ; lacrimal gland; ; iris; ; Region I of hippocampus proper; ; dorsal striatum; ; spermatocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; metal ion binding; protein binding; ubiquitin-protein transferase activity; transferase activity;
Cellular component	cytoplasm; cytosol; centrosome; membrane; postsynaptic density; plasma membrane; microtubule organizing center; cytoskeleton; cytoplasmic vesicle;
Biological process	somitogenesis; endocytosis; negative regulation of neuron differentiation; in utero embryonic development; heart looping; positive regulation of endocytosis; development of the heart; blood vessel development; protein ubiquitination; neural tube formation; Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57534
	225164
	ENSG00000101752
	ENSMUSG00000024294
	Q86YT6
	Q80SY4
	NM_020774
	NM_144860; NM_001364997
	NP_065825
	NP_659109; NP_001351926
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase Mind Bomb 1 (MiB1) is an enzyme that in humans is encoded by the MIB1 gene.^[5] It is involved in regulating apoptosis.^[6]

Confusion with proliferative marker

An antibody directed at the protein Ki-67, a product of the MKI67 gene, is called MIB-1.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101752 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024294 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "MIB1 MIB E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]". Retrieved 6 July 2023.
↑ MIB1. OMIM.URL: https://www.ncbi.nlm.nih.gov/omim/?term=608677. Accessed on: April 24, 2009.
↑ MIB-1. Veripath OncoDiagnostics. http://www.oncodx.org/onco/mib_1.htm Archived 2006-05-28 at the Wayback Machine. Accessed on: April 24, 2009.

Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Wang Z, Tseng CP, Pong RC, et al. (2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
Jin Y, Blue EK, Dixon S, et al. (2003). "A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK". J. Biol. Chem. 277 (49): 46980–6. doi:10.1074/jbc.M208585200. PMC 2824503. PMID 12351649.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Itoh M, Kim CH, Palardy G, et al. (2003). "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta". Dev. Cell. 4 (1): 67–82. doi:10.1016/S1534-5807(02)00409-4. PMID 12530964.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Henshall DC, Schindler CK, So NK, et al. (2004). "Death-associated protein kinase expression in human temporal lobe epilepsy". Ann. Neurol. 55 (4): 485–94. doi:10.1002/ana.20001. PMID 15048887. S2CID 35261517.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yoo KW, Kim EH, Jung SH, et al. (2006). "Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish". FEBS Lett. 580 (18): 4409–16. doi:10.1016/j.febslet.2006.07.009. PMID 16857196. S2CID 37762815.
Song R, Koo BK, Yoon KJ, et al. (2007). "Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1". J. Biol. Chem. 281 (47): 36391–400. doi:10.1074/jbc.M606601200. PMID 17003037.
Zhang L, Nephew KP, Gallagher PJ (2007). "Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes". J. Biol. Chem. 282 (16): 11795–804. doi:10.1074/jbc.M610430200. PMC 2823631. PMID 17324930.
Yakut T, Gutenberg A, Bekar A, et al. (2007). "Correlation of chromosomal imbalances by comparative genomic hybridization and expression of EGFR, PTEN, p53, and MIB-1 in diffuse gliomas". Oncol. Rep. 17 (5): 1037–43. doi:10.3892/or.17.5.1037. PMID 17390041.
van der Avoort IA, van der Laak JA, Paffen A, et al. (2007). "MIB1 expression in basal cell layer: a diagnostic tool to identify premalignancies of the vulva". Mod. Pathol. 20 (7): 770–8. doi:10.1038/modpathol.3800796. hdl:2066/51438. PMID 17464313.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101752 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024294 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "MIB1 MIB E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]". Retrieved 6 July 2023.

[6] MIB1. OMIM.URL: https://www.ncbi.nlm.nih.gov/omim/?term=608677. Accessed on: April 24, 2009.

[7] MIB-1. Veripath OncoDiagnostics. http://www.oncodx.org/onco/mib_1.htm Archived 2006-05-28 at the Wayback Machine. Accessed on: April 24, 2009.

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// Workers AI · dad joke modeWhat did MIB1 say to the alien? You're "men" in blacklisted.

Confusion with proliferative marker

References

Further reading