LYPD1

LYPD1
Identifiers
Aliases	LYPD1, LYPDC1, PHTS, LY6/PLAUR domain containing 1
External IDs	OMIM: 610450; MGI: 1919835; GeneCards: LYPD1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	132,671,579 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	125,840,838 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; ventricular zone; ; hypothalamus; ; amygdala; ; pituitary gland; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	glossopharyngeal ganglion; ; ganglion of vagus nerve; ; dentate gyrus of hippocampal formation granule cell; ; cuneiform bones; ; cranial nervi; ; inferior ganglion of vagus nerve; ; amygdala; ; olfactory nerve; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	acetylcholine receptor binding; acetylcholine receptor inhibitor activity;
Cellular component	membrane; anchored component of membrane; extracellular region; plasma membrane;
Biological process	response to nicotine; behavioral fear response; negative regulation of signaling receptor activity; synaptic transmission, cholinergic; cell activation; acetylcholine receptor signaling pathway; negative regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	116372
	72585
	ENSG00000150551
	ENSMUSG00000026344
	Q8N2G4
	Q8BLC3
	NM_001077427; NM_144586; NM_001321234; NM_001321235
	NM_145100; NM_001311089; NM_001311090
	NP_001070895; NP_001308163; NP_001308164; NP_653187
	NP_001298018; NP_001298019; NP_659568
	Wikidata
View/Edit Human	View/Edit Mouse

Ly6/PLAUR domain-containing protein 1 is a protein that in humans is encoded by the LYPD1 gene.^[5]^[6]

This protein is also known as Lynx2, a member of the Lynx family of neurotransmitter receptor-binding proteins.^[7] Transgenic mice without Lynx2 expression have increased anxiety-related behaviors.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000150551 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026344 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
↑ "Entrez Gene: LYPD1 LY6/PLAUR domain containing 1".
↑ Miwa JM, Lester HA, Walz A (August 2012). "Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction". Physiology. 27 (4). Bethesda, Md.: 187–199. doi:10.1152/physiol.00002.2012. PMID 22875450.
↑ Tekinay AB, Nong Y, Miwa JM, Lieberam I, Ibanez-Tallon I, Greengard P, et al. (March 2009). "A role for LYNX2 in anxiety-related behavior". Proceedings of the National Academy of Sciences of the United States of America. 106 (11): 4477–4482. Bibcode:2009PNAS..106.4477T. doi:10.1073/pnas.0813109106. PMC 2657456. PMID 19246390.

Yu DH, Fan W, Liu G, Nguy V, Chatterton JE, Long S, et al. (April 2006). "PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathway". Experimental Cell Research. 312 (6): 865–876. doi:10.1016/j.yexcr.2005.12.006. PMID 16413018.
Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, et al. (March 2006). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiological Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2005). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000150551 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026344 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Strausberg_2002-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: LYPD1 LY6/PLAUR domain containing 1".

[7] Miwa JM, Lester HA, Walz A (August 2012). "Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction". Physiology. 27 (4). Bethesda, Md.: 187–199. doi:10.1152/physiol.00002.2012. PMID 22875450.

[8] Tekinay AB, Nong Y, Miwa JM, Lieberam I, Ibanez-Tallon I, Greengard P, et al. (March 2009). "A role for LYNX2 in anxiety-related behavior". Proceedings of the National Academy of Sciences of the United States of America. 106 (11): 4477–4482. Bibcode:2009PNAS..106.4477T. doi:10.1073/pnas.0813109106. PMC 2657456. PMID 19246390.

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LYPD1

References

Further reading