LSM8

LSM8
Identifiers
Aliases	LSM8, NAA38, LSM8 homolog, U6 small nuclear RNA associated
External IDs	OMIM: 607288; MGI: 1923772; GeneCards: LSM8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JCR
Gene location (Human)
Chr.	Chromosome 7 (human)
End	118,204,035 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	18,855,750 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; right ventricle; ; ventricular zone; ; monocyte; ; bone marrow; ; bone marrow cell; ; skin of thigh; ; granulocyte; ; oocyte;
	Top expressed in
	primitive streak; ; abdominal wall; ; medial ganglionic eminence; ; hair follicle; ; vas deferens; ; embryo; ; migratory enteric neural crest cell; ; mandibular prominence; ; Gonadal ridge; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; U6 snRNA binding; RNA binding;
Cellular component	spliceosomal complex; nucleus; nucleoplasm; U4/U6 x U5 tri-snRNP complex; U6 snRNP; precatalytic spliceosome; U2-type precatalytic spliceosome; Lsm2-8 complex;
Biological process	mRNA processing; RNA splicing; mRNA splicing, via spliceosome; RNA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51691
	76522
	ENSG00000128534
	ENSMUSG00000044155
	O95777
	Q6ZWM4
	NM_016200
	NM_133939
	NP_057284
	NP_598700
	Wikidata
View/Edit Human	View/Edit Mouse

U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.^[5]^[6]

This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.^[6]

Interactions

LSM8 has been shown to interact with LSM2.^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128534 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044155 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (December 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". The EMBO Journal. 18 (20): 5789–5802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
1 2 "Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
↑ Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
↑ Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–167. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.

Khusial P, Plaag R, Zieve GW (2005). "LSm proteins form heptameric rings that bind to RNA via repeating motifs". Trends in Biochemical Sciences. 30 (9): 522–528. doi:10.1016/j.tibs.2005.07.006. PMID 16051491.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B (1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". The EMBO Journal. 18 (12): 3451–3462. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
Eystathioy T, Peebles CL, Hamel JC, Vaughn JH, Chan EK (March 2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis and Rheumatism. 46 (3): 726–734. doi:10.1002/art.10220. PMID 11920408.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000128534 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044155 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Achsel_1999-5] Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (December 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". The EMBO Journal. 18 (20): 5789–5802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.

[entrez-6] 1 2 "Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

[Lehner_2004_a-7] Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.

[Lehner_2004_b-8] Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–167. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.

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LSM8

Interactions

References

Further reading