LANCL1

LANCL1
Identifiers
Aliases	LANCL1, GPR69A, p40, LanC like 1
External IDs	OMIM: 604155; MGI: 1336997; HomoloGene: 4417; GeneCards: LANCL1; OMA:LANCL1 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E6U, 3E73
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.5.1.18 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 2 (human) Band 2q34 Start 210,431,249 bp End 210,477,652 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C3 Start 67,039,676 bp End 67,078,031 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell corpus callosum inferior ganglion of vagus nerve subthalamic nucleus inferior olivary nucleus Brodmann area 46 pars reticulata postcentral gyrus external globus pallidus lateral nuclear group of thalamus Top expressed in seminiferous tubule spermatid spermatocyte corneal stroma primary oocyte facial motor nucleus anterior horn of spinal cord barrel cortex cingulate gyrus olfactory tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function SH3 domain binding low-density lipoprotein particle receptor binding zinc ion binding protein binding G protein-coupled receptor activity metal ion binding glutathione binding catalytic activity glutathione transferase activity transferase activity Cellular component cytoplasm integral component of plasma membrane membrane plasma membrane Biological process G protein-coupled receptor signaling pathway regulation of neuron apoptotic process regulation of oxidative stress-induced neuron death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10314 14768 Ensembl ENSG00000115365 ENSMUSG00000026000 UniProt O43813 O89112 RefSeq (mRNA) NM_001136574 NM_001136575 NM_006055 NM_001190984 NM_001190985 NM_021295 RefSeq (protein) NP_001130046 NP_001130047 NP_006046 NP_001177913 NP_001177914 NP_067270 Location (UCSC) Chr 2: 210.43 – 210.48 Mb Chr 1: 67.04 – 67.08 Mb PubMed search
Wikidata
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LanC like 1 is a protein that in humans is encoded by the LANCL1 gene.

Function

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Further reading

• Zhang W, Wang L, Liu Y, Xu J, Zhu G, Cang H, Li X, Bartlam M, Hensley K, Li G, Rao Z, Zhang XC (2009). "Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione". Genes Dev. 23 (12): 1387–92. doi:10.1101/gad.1789209. PMC 2701572. PMID 19528316.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.