KRT85
| KRT85 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | KRT85, ECTD4, HB5, Hb-5, K85, KRTHB5, hHb5, keratin 85 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602767; MGI: 1859268; GeneCards: KRT85 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.[5][6][7]
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.[7]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000135443 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000116336 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Rogers MA, Langbein L, Praetzel S, Moll I, Krieg T, Winter H, et al. (April 1997). "Sequences and differential expression of three novel human type-II hair keratins". Differentiation; Research in Biological Diversity. 61 (3): 187–194. doi:10.1046/j.1432-0436.1997.6130187.x. PMID 9084137.
- ↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–174. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
- 1 2 "Entrez Gene: KRT85 keratin 85".
Further reading
[edit]- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Naeem M, Wajid M, Lee K, Leal SM, Ahmad W (March 2006). "A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type". Journal of Medical Genetics. 43 (3): 274–279. doi:10.1136/jmg.2005.033381. PMC 2563238. PMID 16525032.
- Tang K, Finley RL, Nie D, Honn KV (March 2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening". Biochemistry. 39 (12): 3185–3191. doi:10.1021/bi992664v. PMID 10727209.
- Rogers MA, Winter H, Langbein L, Wolf C, Schweizer J (March 2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain". The Journal of Investigative Dermatology. 114 (3): 464–472. doi:10.1046/j.1523-1747.2000.00910.x. PMID 10692104.
- Langbein L, Rogers MA, Winter H, Praetzel S, Beckhaus U, Rackwitz HR, et al. (July 1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". The Journal of Biological Chemistry. 274 (28): 19874–19884. doi:10.1074/jbc.274.28.19874. PMID 10391933.
- Rogers MA, Winter H, Langbein L, Krieg T, Schweizer J (October 1996). "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5". The Journal of Investigative Dermatology. 107 (4): 633–638. doi:10.1111/1523-1747.ep12584243. PMID 8823373.
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