// Workers AI · dad joke modeWhat did KLK2 say to KLK1? "Klick" with me.

KLK2
Identifiers
Aliases	KLK2, KLK2A2, hGK-1, hK2, kallikrein related peptidase 2
External IDs	OMIM: 147960; HomoloGene: 124422; GeneCards: KLK2; OMA:KLK2 - orthologs
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4NFE, 4NFF
Enzyme activity
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,880,567 bp
RNA expression pattern
	Top expressed in
	prostate; ; right testis; ; left testis; ; male germ cell; ; sperm; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; testicle; ; thymus; ; urethra;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity;
Cellular component	extracellular region; extracellular exosome; secretory granule;
Biological process	extracellular matrix disassembly; proteolysis; regulation of systemic arterial blood pressure; zymogen activation;
	Sources:Amigo / QuickGO
Orthologs
	3817
	n/a
	ENSG00000167751
	n/a
	P20151
	n/a
	NM_001002231; NM_001002232; NM_001256080; NM_005551
	n/a
	NP_001002231; NP_001243009; NP_005542
	n/a
	Wikidata
View/Edit Human

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene. Like others in the kallikrein family, it is a protease enzyme, which means it participates in breaking bonds between amino acids in proteins and/or peptides. KLK2 is particularly associated with prostatic tissue, where it is involved in activating the related enzyme prostate-specific antigen (aka KLK3).^[3]^[4]^[5]^[6] It accomplishes this by cleaving off certain amino acids from inactive precursor of prostate-specific antigen (called proPSA).^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167751 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Riegman PH, Vlietstra RJ, Klaassen P, van der Korput JA, Geurts van Kessel A, Romijn JC, et al. (April 1989). "The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19". FEBS Letters. 247 (1): 123–126. Bibcode:1989FEBSL.247..123R. doi:10.1016/0014-5793(89)81253-0. PMID 2468530. S2CID 37763337.
↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
↑ "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. June 2006. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
↑ "Entrez Gene: KLK2 Kallikrein-related peptidase 2".
↑ Lövgren J, Airas K, Lilja H (June 1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors". European Journal of Biochemistry. 262 (3): 781–789. doi:10.1046/j.1432-1327.1999.00433.x. PMID 10411640.

Riegman PH, Vlietstra RJ, van der Korput HA, Romijn JC, Trapman J (April 1991). "Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species". Molecular and Cellular Endocrinology. 76 (1–3): 181–190. doi:10.1016/0303-7207(91)90272-T. PMID 1726490. S2CID 29689514.
Qin H, Kemp J, Yip MY, Lam-Po-Tang PR, Morris BJ (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization". Human Heredity. 41 (4): 222–226. doi:10.1159/000154005. PMID 1783409.
Schedlich LJ, Bennetts BH, Morris BJ (October 1987). "Primary structure of a human glandular kallikrein gene". DNA. 6 (5): 429–437. doi:10.1089/dna.1987.6.429. PMID 2824146.
Frenette G, Deperthes D, Tremblay RR, Lazure C, Dubé JY (February 1997). "Purification of enzymatically active kallikrein hK2 from human seminal plasma". Biochimica et Biophysica Acta (BBA) - General Subjects. 1334 (1): 109–115. doi:10.1016/s0304-4165(96)00080-3. PMID 9042371.
Bourgeois L, Brillard-Bourdet M, Deperthes D, Juliano MA, Juliano L, Tremblay RR, et al. (November 1997). "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2". The Journal of Biological Chemistry. 272 (47): 29590–29595. doi:10.1074/jbc.272.47.29590. PMID 9368023.
Mikolajczyk SD, Millar LS, Kumar A, Saedi MS (January 1998). "Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors". The Prostate. 34 (1): 44–50. doi:10.1002/(SICI)1097-0045(19980101)34:1<44::AID-PROS6>3.0.CO;2-K. PMID 9428387. S2CID 23179822.
Yu DC, Sakamoto GT, Henderson DR (April 1999). "Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy". Cancer Research. 59 (7): 1498–1504. PMID 10197620.
Mikolajczyk SD, Millar LS, Kumar A, Saedi MS (May 1999). "Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1". International Journal of Cancer. 81 (3): 438–442. doi:10.1002/(SICI)1097-0215(19990505)81:3<438::AID-IJC18>3.0.CO;2-U. PMID 10209959.
Lövgren J, Valtonen-André C, Marsal K, Lilja H, Lundwall A (1999). "Measurement of prostate-specific antigen and human glandular kallikrein 2 in different body fluids". Journal of Andrology. 20 (3): 348–355. doi:10.1002/j.1939-4640.1999.tb02528.x. PMID 10386814.
Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, et al. (July 1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nature Genetics. 22 (3): 231–238. doi:10.1038/10290. PMID 10391209. S2CID 195213008.
Mikolajczyk SD, Millar LS, Marker KM, Rittenhouse HG, Wolfert RL, Marks LS, et al. (August 1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue". Cancer Research. 59 (16): 3927–3930. PMID 10463585.
Liu XF, Essand M, Vasmatzis G, Lee B, Pastan I (November 1999). "Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing". Biochemical and Biophysical Research Communications. 264 (3): 833–839. Bibcode:1999BBRC..264..833L. doi:10.1006/bbrc.1999.1595. PMID 10544017.
Ren F, Zhang S, Mitchell SH, Butler R, Young CY (April 2000). "Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells". Oncogene. 19 (15): 1924–1932. doi:10.1038/sj.onc.1203511. PMID 10773882.
Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA (December 2000). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". The Journal of Biological Chemistry. 275 (48): 37397–37406. doi:10.1074/jbc.M004525200. PMID 10969073.
Chen VC, Chao L, Chao J (December 2000). "A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein". The Journal of Biological Chemistry. 275 (51): 40371–40377. doi:10.1074/jbc.M005691200. PMID 10991942.
Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, et al. (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–130. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
Réhault S, Monget P, Mazerbourg S, Tremblay R, Gutman N, Gauthier F, et al. (May 2001). "Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3". European Journal of Biochemistry. 268 (10): 2960–2968. doi:10.1046/j.1432-1327.2001.02185.x. PMID 11358513.
Saedi MS, Zhu Z, Marker K, Liu RS, Carpenter PM, Rittenhouse H, et al. (November 2001). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells". International Journal of Cancer. 94 (4): 558–563. doi:10.1002/ijc.1501. PMID 11745444. S2CID 2826757.

External links

The MEROPS online database for peptidases and their inhibitors: S01.161^{[permanent dead link]}
Overview of all the structural information available in the PDB for UniProt: P20151 (Human Kallikrein-2) at the PDBe-KB.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167751 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Riegman_1989-3] Riegman PH, Vlietstra RJ, Klaassen P, van der Korput JA, Geurts van Kessel A, Romijn JC, et al. (April 1989). "The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19". FEBS Letters. 247 (1): 123–126. Bibcode:1989FEBSL.247..123R. doi:10.1016/0014-5793(89)81253-0. PMID 2468530. S2CID 37763337.

[Lundwall_2006-4] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid16800723-5] "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. June 2006. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[6] "Entrez Gene: KLK2 Kallikrein-related peptidase 2".

[7] Lövgren J, Airas K, Lilja H (June 1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors". European Journal of Biochemistry. 262 (3): 781–789. doi:10.1046/j.1432-1327.1999.00433.x. PMID 10411640.

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References

Further reading

External links