// Workers AI · dad joke modeWhat did KAT2A say to its friend? Purr-haps we'll meet again.

KAT2A
Identifiers
Aliases	KAT2A, GCN5, GCN5L2, PCAF-b, hGCN5, lysine acetyltransferase 2A
External IDs	OMIM: 602301; MGI: 1343101; HomoloGene: 41343; GeneCards: KAT2A; OMA:KAT2A - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F68, 1Z4R, 3D7C, 5H86, 5H84
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.1.48 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.2 Start 42,113,111 bp End 42,121,367 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 63.53 cM Start 100,595,572 bp End 100,603,291 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left ovary right ovary right hemisphere of cerebellum right adrenal cortex right frontal lobe left uterine tube left adrenal cortex body of uterus canal of the cervix Top expressed in internal carotid artery external carotid artery otic placode tail of embryo otic vesicle saccule genital tubercle epiblast lacrimal gland hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity transcription coactivator activity N-acetyltransferase activity transcription factor binding histone deacetylase binding chromatin binding H3 histone acetyltransferase activity protein binding acetyltransferase activity histone acetyltransferase activity (H4-K12 specific) protein phosphatase binding acyltransferase activity histone acetyltransferase activity thiol-dependent deubiquitinase peptide-lysine-N-acetyltransferase activity histone succinyltransferase activity Cellular component transcription factor TFTC complex nucleoplasm histone acetyltransferase complex mitotic spindle extracellular space nucleus chromosome cytoplasm centrosome microtubule organizing center cytoskeleton oxoglutarate dehydrogenase complex Biological process positive regulation of transcription regulatory region DNA binding somitogenesis epigenetic maintenance of chromatin in transcription-competent conformation chromatin remodeling metencephalon development cellular response to nerve growth factor stimulus regulation of transcription, DNA-templated regulation of protein stability response to organic cyclic compound multicellular organism growth positive regulation of protein targeting to mitochondrion regulation of transcription by RNA polymerase II cardiac muscle cell differentiation cellular response to tumor necrosis factor histone H3-K14 acetylation positive regulation of cell projection organization in utero embryonic development transcription by RNA polymerase II transcription, DNA-templated nervous system development positive regulation of histone acetylation histone deubiquitination telencephalon development neural tube closure response to nutrient levels regulation of autophagy of mitochondrion histone acetylation histone H3 acetylation cell population proliferation viral process intracellular distribution of mitochondria histone H4-K12 acetylation alpha-tubulin acetylation midbrain development protein deubiquitination cytokine production development of the heart long-term memory internal peptidyl-lysine acetylation regulation of regulatory T cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of centriole replication regulation of synaptic plasticity regulation of T cell activation limb development histone succinylation positive regulation of cardiac muscle cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2648 14534 Ensembl ENSG00000108773 ENSMUSG00000020918 UniProt Q92830 Q9JHD2 RefSeq (mRNA) NM_021078 NM_001376227 NM_001038010 NM_020004 RefSeq (protein) NP_066564 NP_001363156 NP_001033099 NP_064388 Location (UCSC) Chr 17: 42.11 – 42.12 Mb Chr 11: 100.6 – 100.6 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene.

KAT2A also acetylates non-histone proteins, including the transcription factor PAX6, promoting its ubiquitination and proteasomal degradation and thereby influencing the balance between proliferation and neuronal differentiation in neural stem cells.

Interactions

GCN5L2 has been shown to interact with:

• DDB1,
• Ku70,
• Ku80,
• TADA2L,
• TAF9, and
• Transcription initiation protein SPT3 homolog.

Further reading

• Berry R, Stevens TJ, Walter NA, Wilcox AS, Rubano T, Hopkins JA, et al. (1995). "Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map". Nature Genetics. 10 (4): 415–423. doi:10.1038/ng0895-415. PMID 7670491. S2CID 22277955.
• Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y (1996). "A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A". Nature. 382 (6589): 319–324. Bibcode:1996Natur.382..319Y. doi:10.1038/382319a0. PMID 8684459. S2CID 4328685.
• Carter KC, Wang L, Shell BK, Zamir I, Berger SL, Moore PA (1997). "The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern". Genomics. 40 (3): 497–500. doi:10.1006/geno.1996.4605. PMID 9073520.
• Smith ER, Belote JM, Schiltz RL, Yang XJ, Moore PA, Berger SL, et al. (1998). "Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members". Nucleic Acids Research. 26 (12): 2948–2954. doi:10.1093/nar/26.12.2948. PMC 147644. PMID 9611240.
• Randhawa GS, Bell DW, Testa JR, Feinberg AP (1998). "Identification and mapping of human histone acetylation modifier gene homologues". Genomics. 51 (2): 262–269. doi:10.1006/geno.1998.5370. PMID 9722949.
• Xu W, Edmondson DG, Roth SY (1998). "Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates". Molecular and Cellular Biology. 18 (10): 5659–5669. doi:10.1128/MCB.18.10.5659. PMC 109152. PMID 9742083.
• Brand M, Yamamoto K, Staub A, Tora L (1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". The Journal of Biological Chemistry. 274 (26): 18285–18289. doi:10.1074/jbc.274.26.18285. PMID 10373431.
• McMahon SB, Wood MA, Cole MD (2000). "The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc". Molecular and Cellular Biology. 20 (2): 556–562. doi:10.1128/MCB.20.2.556-562.2000. PMC 85131. PMID 10611234.
• Kurooka H, Honjo T (2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–17220. doi:10.1074/jbc.M000909200. PMID 10747963.
• Hudson BP, Martinez-Yamout MA, Dyson HJ, Wright PE (2000). "Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain". Journal of Molecular Biology. 304 (3): 355–370. doi:10.1006/jmbi.2000.4207. PMID 11090279.
• Col E, Caron C, Seigneurin-Berny D, Gracia J, Favier A, Khochbin S (2001). "The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat". The Journal of Biological Chemistry. 276 (30): 28179–28184. doi:10.1074/jbc.M101385200. PMID 11384967.
• Gangloff YG, Pointud JC, Thuault S, Carré L, Romier C, Muratoglu S, et al. (2001). "The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger". Molecular and Cellular Biology. 21 (15): 5109–5121. doi:10.1128/MCB.21.15.5109-5121.2001. PMC 87236. PMID 11438666.
• Brès V, Kiernan R, Emiliani S, Benkirane M (2002). "Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication". The Journal of Biological Chemistry. 277 (25): 22215–22221. doi:10.1074/jbc.M201895200. PMID 11956210.
• Col E, Gilquin B, Caron C, Khochbin S (2002). "Tat-controlled protein acetylation". The Journal of Biological Chemistry. 277 (40): 37955–37960. doi:10.1074/jbc.M206694200. PMID 12154097.

External links

• FactorBook GCN5