// Workers AI · dad joke modeWhy did IG HG4 go to therapy? It had high G issues.

IGHG4
Identifiers
Aliases	IGHG4, immunoglobulin heavy constant gamma 4 (G4m marker)
External IDs	OMIM: 147130; GeneCards: IGHG4; OMA:IGHG4 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.33 Start 105,620,506 bp End 105,626,066 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix duodenum spleen gallbladder bone marrow cell mucosa of transverse colon lymph node rectum right lobe of liver right coronary artery n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 3503 n/a Ensembl ENSG00000211892 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.62 – 105.63 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Ig gamma-4 chain C region is a protein that in humans is encoded by the IGHG4 gene.

See also

• Immunoglobulin heavy chain (IGH)
• Immunoglobulin G (IgG)
  • Subclasses of IgG, IgG4 is encoded by this gene
• IgG4-related disease

Further reading

• McLean GR, Nakouzi A, Casadevall A, Green NS (Oct 2000). "Human and murine immunoglobulin expression vector cassettes". Molecular Immunology. 37 (14): 837–45. doi:10.1016/S0161-5890(00)00101-2. PMID 11257305.
• Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 79 (6): 1984–8. Bibcode:1982PNAS...79.1984E. doi:10.1073/pnas.79.6.1984. PMC 346106. PMID 6804948.
• Flanagan JG, Lefranc MP, Rabbitts TH (Mar 1984). "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences". Cell. 36 (3): 681–8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489. S2CID 54312675.
• Hisajima H, Nishida Y, Nakai S, Takahashi N, Ueda S, Honjo T (May 1983). "Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin". Proceedings of the National Academy of Sciences of the United States of America. 80 (10): 2995–9. doi:10.1073/pnas.80.10.2995. PMC 393960. PMID 6407005.
• Ueda S, Nakai S, Nishida Y, Hisajima H, Honjo T (1984). "Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns". The EMBO Journal. 1 (12): 1539–44. doi:10.1002/j.1460-2075.1982.tb01352.x. PMC 553248. PMID 6327276.
• Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene". DNA. 1 (1): 11–8. doi:10.1089/dna.1.1981.1.11. PMID 6299662.
• Pink JR, Buttery SH, De Vries GM, Milstein C (Mar 1970). "Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain". The Biochemical Journal. 117 (1): 33–47. doi:10.1042/bj1170033. PMC 1178827. PMID 4192699.