// Workers AI · dad joke modeWhy did IGHG2 go to therapy? It had a heavy chain reaction.

IGHG2
Identifiers
Aliases	IGHG2, immunoglobulin heavy constant gamma 2 (G2m marker)
External IDs	OMIM: 147110; GeneCards: IGHG2; OMA:IGHG2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.33 Start 105,639,559 bp End 105,644,790 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix spleen bone marrow cell rectum lymph node duodenum right coronary artery mucosa of transverse colon olfactory zone of nasal mucosa gallbladder n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 3501 n/a Ensembl ENSG00000211893 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.64 – 105.64 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Ig gamma-2 chain C region is a protein that in humans is encoded by the IGHG2 gene.

Further reading

• Connell GE, Parr DM, Hofmann T (Jun 1979). "The amino acid sequences of the three heavy chain constant region domains of a human IgG2 myeloma protein". Canadian Journal of Biochemistry. 57 (6): 758–67. doi:10.1139/o79-094. PMID 113060.
• Hofmann T, Parr DM (Nov 1979). "A note of the amino acid sequence of residues 381--391 of human immunoglobulins gamma chains". Molecular Immunology. 16 (11): 923–5. doi:10.1016/0161-5890(79)90091-9. PMID 118920.
• Milstein C, Frangione B (Jan 1971). "Disulphide bridges of the heavy chain of human immunoglobulin G2". The Biochemical Journal. 121 (2): 217–25. doi:10.1042/bj1210217. PMC 1176558. PMID 4940472.
• Frangione B, Milstein C, Pink JR (Jan 1969). "Structural studies of immunoglobulin G". Nature. 221 (5176): 145–8. doi:10.1038/221145a0. PMID 5782707. S2CID 4289483.
• Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene". DNA. 1 (1): 11–8. doi:10.1089/dna.1.1981.1.11. PMID 6299662.
• Ueda S, Nakai S, Nishida Y, Hisajima H, Honjo T (1984). "Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns". The EMBO Journal. 1 (12): 1539–44. doi:10.1002/j.1460-2075.1982.tb01352.x. PMC 553248. PMID 6327276.
• Krawinkel U, Rabbitts TH (1984). "Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes". The EMBO Journal. 1 (4): 403–7. doi:10.1002/j.1460-2075.1982.tb01182.x. PMC 553059. PMID 6329676.
• Hisajima H, Nishida Y, Nakai S, Takahashi N, Ueda S, Honjo T (May 1983). "Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin". Proceedings of the National Academy of Sciences of the United States of America. 80 (10): 2995–9. doi:10.1073/pnas.80.10.2995. PMC 393960. PMID 6407005.
• Flanagan JG, Lefranc MP, Rabbitts TH (Mar 1984). "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences". Cell. 36 (3): 681–8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489. S2CID 54312675.
• Wang AC, Tung E, Fudenberg HH (Sep 1980). "The primary structure of a human IgG2 heavy chain: genetic, evolutionary, and functional implications". Journal of Immunology. 125 (3): 1048–54. doi:10.4049/jimmunol.125.3.1048. PMID 6774012.
• Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 79 (6): 1984–8. Bibcode:1982PNAS...79.1984E. doi:10.1073/pnas.79.6.1984. PMC 346106. PMID 6804948.
• Takahashi N, Ueda S, Obata M, Nikaido T, Nakai S, Honjo T (Jun 1982). "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family". Cell. 29 (2): 671–9. doi:10.1016/0092-8674(82)90183-0. PMID 6811139. S2CID 31733882.
• Stoppini M, Bellotti V, Negri A, Merlini G, Garver F, Ferri G (Mar 1995). "Characterization of the two unique human anti-flavin monoclonal immunoglobulins". European Journal of Biochemistry. 228 (3): 886–93. doi:10.1111/j.1432-1033.1995.tb20336.x. PMID 7737190.
• McLean GR, Nakouzi A, Casadevall A, Green NS (Oct 2000). "Human and murine immunoglobulin expression vector cassettes". Molecular Immunology. 37 (14): 837–45. doi:10.1016/S0161-5890(00)00101-2. PMID 11257305.
• Kristiansen TZ, Bunkenborg J, Gronborg M, Molina H, Thuluvath PJ, Argani P, Goggins MG, Maitra A, Pandey A (Jul 2004). "A proteomic analysis of human bile" (PDF). Molecular & Cellular Proteomics. 3 (7): 715–28. doi:10.1074/mcp.M400015-MCP200. PMID 15084671. S2CID 15743023.
• Jönsson G, Oxelius VA, Truedsson L, Braconier JH, Sturfelt G, Sjöholm AG (Jul 2006). "Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency". Journal of Immunology. 177 (1): 722–8. doi:10.4049/jimmunol.177.1.722. PMID 16785571.
• Lee EB, Lee YJ, Shin DH, Choi YM, Park MH, Pandey JP, Song YW (Jan 2007). "Immunoglobulin GM and KM genotypes in Korean patients with systemic lupus erythematosus". Rheumatology International. 27 (3): 219–24. doi:10.1007/s00296-006-0192-6. PMID 16944158. S2CID 21100035.