HS3ST1

HS3ST1
Identifiers
Aliases	HS3ST1, 3OST, 3OST1, heparan sulfate-glucosamine 3-sulfotransferase 1
External IDs	OMIM: 603244; MGI: 1201606; HomoloGene: 3751; GeneCards: HS3ST1; OMA:HS3ST1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZRH
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	11,429,564 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	39,912,818 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; bronchial epithelial cell; ; mucosa of paranasal sinus; ; left ovary; ; caput epididymis; ; oral cavity; ; buccal mucosa cell; ; right ovary; ; palpebral conjunctiva; ; epithelium of nasopharynx;
	Top expressed in
	cerebellar cortex; ; cumulus cell; ; lobe of cerebellum; ; olfactory bulb; ; dentate gyrus of hippocampal formation granule cell; ; gray matter layer of cerebellum; ; cerebellar vermis; ; primary visual cortex; ; ventricular zone; ; barrel cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; [heparan sulfate-glucosamine 3-sulfotransferase 1 activity]; heparan sulfate sulfotransferase activity;
Cellular component	Golgi lumen; integral component of membrane; Golgi apparatus;
Biological process	glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9957
	15476
	ENSG00000002587
	ENSMUSG00000051022
	O14792
	O35310
	NM_005114
	NM_010474
	NP_005105
	NP_034604
	Wikidata
View/Edit Human	View/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.^[5]^[6]

Function

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.^[6]

Clinical significance

Polymorphisms in HS3ST1 appear to be a risk factor for developing Alzheimer's disease.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000002587 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051022 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (February 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". The Journal of Biological Chemistry. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.
1 2 "Entrez Gene: HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1".
↑ Witoelar A, Rongve A, Almdahl IS, et al. (2018-12-27). "Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci". Scientific Reports. 8 (1): 18088. Bibcode:2018NatSR...818088W. doi:10.1038/s41598-018-36429-6. PMC 6308232. PMID 30591712.

External links

Overview of all the structural information available in the PDB for UniProt: O14792 (Human Heparan sulfate glucosamine 3-O-sulfotransferase 1) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: O35310 (Mouse Heparan sulfate glucosamine 3-O-sulfotransferase 1) at the PDBe-KB.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000002587 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051022 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9988767-5] Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (February 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". The Journal of Biological Chemistry. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.

[entrez-6] 1 2 "Entrez Gene: HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1".

[7] Witoelar A, Rongve A, Almdahl IS, et al. (2018-12-27). "Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci". Scientific Reports. 8 (1): 18088. Bibcode:2018NatSR...818088W. doi:10.1038/s41598-018-36429-6. PMC 6308232. PMID 30591712.

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HS3ST1

Function

Clinical significance

References

Further reading

External links