HEPACAM2

HEPACAM2
Identifiers
Aliases	HEPACAM2, MIKI, HEPACAM family member 2
External IDs	OMIM: 614133; MGI: 2141520; GeneCards: HEPACAM2
Gene location (Human) Chr. Chromosome 7 (human) Band 7q21.2 Start 93,188,534 bp End 93,226,469 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A1 Start 3,457,096 bp End 3,498,298 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of sigmoid colon rectum islet of Langerhans palpebral conjunctiva mucosa of transverse colon jejunal mucosa testicle duodenum human kidney Top expressed in islet of Langerhans left colon crypt of lieberkuhn of small intestine ileum jejunum duodenum intestinal villus Paneth cell right kidney spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm microtubule organizing center integral component of membrane Golgi membrane centrosome cytoskeleton membrane Golgi apparatus spindle midbody Biological process cell cycle cell division centrosome cycle Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 253012 101202 Ensembl ENSG00000188175 ENSMUSG00000044156 UniProt A8MVW5 Q4VAH7 RefSeq (mRNA) NM_001039372 NM_001288804 NM_001288810 NM_198151 NM_001346642 NM_178899 RefSeq (protein) NP_001034461 NP_001275733 NP_001275739 NP_001333571 NP_937794 NP_849230 Location (UCSC) Chr 7: 93.19 – 93.23 Mb Chr 6: 3.46 – 3.5 Mb PubMed search
Wikidata
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HEPACAM family member 2 is a protein that in humans is encoded by the HEPACAM2 gene.

Function

This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology, and apoptosis.

Poly (ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.