// Workers AI · dad joke modeWhat did GZMM say to its date? You're gzmm-azing

GZMM
Identifiers
Aliases	GZMM, LMET1, MET1, granzyme M
External IDs	OMIM: 600311; MGI: 99549; HomoloGene: 21099; GeneCards: GZMM; OMA:GZMM - orthologs
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2ZGC, 2ZGH, 2ZGJ, 2ZKS
Gene location (Human)
Chr.	Chromosome 19 (human)
End	549,924 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,531,095 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; lymph node; ; appendix; ; mucosa of transverse colon; ; thymus; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; bone marrow;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; morula; ; retinal pigment epithelium; ; interventricular septum; ; olfactory epithelium; ; embryo; ; embryo; ; granulocyte; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; endopeptidase activity; serine-type endopeptidase activity; hydrolase activity; protein binding;
Cellular component	extracellular region; membrane;
Biological process	innate immune response; cell death; cytolysis; proteolysis; immune system process; apoptotic process; T cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	3004
	16904
	ENSG00000197540
	ENSMUSG00000054206
	P51124
	n/a
	NM_005317; NM_001258351
	NM_008504; NM_001302485; NM_001302499
	NP_001245280; NP_005308
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Granzyme M is a protein that in humans is encoded by the GZMM gene.^[5]^[6]

Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197540 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054206 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Baker E, Sutherland GR, Smyth MJ (Apr 1994). "The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3". Immunogenetics. 39 (4): 294–5. doi:10.1007/bf00188796. PMID 8119738. S2CID 33990020.
1 2 "Entrez Gene: GZMM granzyme M (lymphocyte met-ase 1)".

Smyth MJ, O'Connor MD, Trapani JA (1996). "Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies". J. Leukoc. Biol. 60 (5): 555–62. doi:10.1002/jlb.60.5.555. PMID 8929545. S2CID 19732623.
Pilat D, Fink T, Obermaier-Skrobanek B, et al. (1995). "The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3". Genomics. 24 (3): 445–50. doi:10.1006/geno.1994.1651. PMID 7713495.
Smyth MJ, Sayers TJ, Wiltrout T, et al. (1994). "Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells". J. Immunol. 151 (11): 6195–205. doi:10.4049/jimmunol.151.11.6195. PMID 8245461.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Krenacs L, Smyth MJ, Bagdi E, et al. (2003). "The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity". Blood. 101 (9): 3590–3. doi:10.1182/blood-2002-09-2908. PMID 12506019.
Kelly JM, Waterhouse NJ, Cretney E, et al. (2004). "Granzyme M mediates a novel form of perforin-dependent cell death". J. Biol. Chem. 279 (21): 22236–42. doi:10.1074/jbc.M401670200. PMID 15028722.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mahrus S, Kisiel W, Craik CS (2005). "Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B." J. Biol. Chem. 279 (52): 54275–82. doi:10.1074/jbc.M411482200. PMID 15494398.
Lu H, Hou Q, Zhao T, et al. (2006). "Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation". J. Immunol. 177 (2): 1171–8. doi:10.4049/jimmunol.177.2.1171. PMID 16818775.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197540 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054206 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8119738-5] Baker E, Sutherland GR, Smyth MJ (Apr 1994). "The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3". Immunogenetics. 39 (4): 294–5. doi:10.1007/bf00188796. PMID 8119738. S2CID 33990020.

[entrez-6] 1 2 "Entrez Gene: GZMM granzyme M (lymphocyte met-ase 1)".

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References

Further reading