GAS5
| GAS5 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | GAS5, NCRNA00030, SNHG2, growth arrest specific 5 (non-protein coding) | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608280; GeneCards: GAS5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Growth arrest-specific 5 is a non-protein coding RNA that in humans is encoded by the GAS5 gene.[3][4]
Gene
[edit]The GAS5 introns host several snoRNA sequences, including SNORD81, SNORD47, SNORD80, SNORD79, SNORD78, SNORD44, SNORD77, SNORD76, SNORD75 and SNORD74.[4][5][6][7] These intronic sequences are more conserved than the exons of the host gene, these sorts of genes are often called "inside-out genes".[8]
Function
[edit]GAS5 noncoding RNA, which accumulates in growth arrested cells, acts as a decoy hormone response element for the glucocorticoid receptor (GR) and hence blocks the upregulation of gene expression by activated GR.[9][10]
It was recently discovered that the nonsense-mediated degradation pathway can regulate the function of the GAS5 in mammalian cells.[11]
Clinical significance
[edit]A number of studies have linked GAS5 to apoptosis and it may play a role in the progression of some types of cancer.[12][13][14]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000234741 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: growth arrest-specific 5 (non-protein coding)".
- 1 2 Smith CM, Steitz JA (December 1998). "Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes". Molecular and Cellular Biology. 18 (12): 6897–6909. doi:10.1128/mcb.18.12.6897. PMC 109273. PMID 9819378.
- ↑ Tanaka R, Satoh H, Moriyama M, Satoh K, Morishita Y, Yoshida S, et al. (2000). "Intronic U50 small-nucleolar-RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma". Genes to Cells. 5 (4): 277–287. doi:10.1046/j.1365-2443.2000.00325.x. PMID 10792466.
- ↑ Raho G, Barone V, Rossi D, Philipson L, Sorrentino V (2000). "The gas 5 gene shows four alternative splicing patterns without coding for a protein". Gene. 256 (1–2): 13–17. doi:10.1016/S0378-1119(00)00363-2. PMID 11054530.
- ↑ Hirose T, Steitz JA (2001). "Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 98 (23): 12914–12919. Bibcode:2001PNAS...9812914H. doi:10.1073/pnas.231490998. PMC 60799. PMID 11606788.
- ↑ Eddy SR (December 1999). "Noncoding RNA genes". Current Opinion in Genetics & Development. 9 (6): 695–699. doi:10.1016/S0959-437X(99)00022-2. PMID 10607607.
- ↑ Kino T, Hurt DE, Ichijo T, Nader N, Chrousos GP (2010). "Noncoding RNA Gas5 Is a Growth Arrest and Starvation-Associated Repressor of the Glucocorticoid Receptor". Science Signaling. 3 (107): ra8. doi:10.1126/scisignal.2000568. PMC 2819218. PMID 20124551.
- ↑ Garabedian MJ, Logan SK (2010). "Glucocorticoid receptor DNA binding decoy is a gas". Science Signaling. 3 (108): pe5. doi:10.1126/scisignal.3108pe5. PMID 20145207. S2CID 21089519.
- ↑ Tani H, Torimura M, Akimitsu N (2013). "The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells". PLOS ONE. 8 (1): e556884. Bibcode:2013PLoSO...855684T. doi:10.1371/journal.pone.0055684. PMC 3559549. PMID 23383264.
- ↑ Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F, Williams GT (2009). "GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer". Oncogene. 28 (2): 195–208. doi:10.1038/onc.2008.373. PMID 18836484. S2CID 9209496.
- ↑ Nakamura Y, Takahashi N, Kakegawa E, Yoshida K, Ito Y, Kayano H, et al. (2008). "The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma". Cancer Genetics and Cytogenetics. 182 (2): 144–149. doi:10.1016/j.cancergencyto.2008.01.013. PMID 18406879.
- ↑ Mourtada-Maarabouni M, Hedge VL, Kirkham L, Farzaneh F, Williams GT (2008). "Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5)". Journal of Cell Science. 121 (Pt 7): 939–946. doi:10.1242/jcs.024646. PMID 18354083. S2CID 218512.
 | This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information. |