// Workers AI · dad joke modeWhat did GALNT13 say? "I'm a glyco enzyme, it's a gal thing.

GALNT13
Identifiers
Aliases	GALNT13, GalNAc-T13, polypeptide N-acetylgalactosaminyltransferase 13
External IDs	OMIM: 608369; MGI: 2139447; GeneCards: GALNT13
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	154,453,979 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	55,118,309 bp
RNA expression pattern
	Top expressed in
	cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; gonad; ; corpus callosum; ; testicle; ; C1 segment; ; Achilles tendon; ; secondary oocyte; ; cerebellar vermis;
	Top expressed in
	lobe of cerebellum; ; habenula; ; cerebellar vermis; ; dorsal striatum; ; lumbar spinal ganglion; ; olfactory tubercle; ; lateral septal nucleus; ; nucleus accumbens; ; substantia nigra; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; metal ion binding; carbohydrate binding; polypeptide N-acetylgalactosaminyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	protein glycosylation; O-glycan processing; protein O-linked glycosylation; protein O-linked glycosylation via serine; protein O-linked glycosylation via threonine;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	114805
	271786
	ENSG00000144278
	ENSMUSG00000060988
	Q8IUC8
	Q8CF93
	NM_001301627; NM_052917
	NM_173030
NP_001288556; NP_443149; NP_001363321; NP_001363323; NP_001363327;
	NP_001363329; NP_001363330; NP_001363331; NP_001363332; NP_001363333; NP_001363334
	NP_766618
	Wikidata
View/Edit Human	View/Edit Mouse

Polypeptide N-acetylgalactosaminyltransferase 13 is an enzyme that in humans is encoded by the GALNT13 gene.^[5]^[6]^[7]

The GALNT13 protein is a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAcT; EC 2.4.1.41) family, which initiate O-linked glycosylation of mucins (see MUC3A, MIM 158371) by the initial transfer of N-acetylgalactosamine (GalNAc) with an alpha-linkage to a serine or threonine residue.[supplied by OMIM]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000144278 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060988 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Kikuno R, Ohara O (September 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Research. 8 (4): 179–187. doi:10.1093/dnares/8.4.179. PMID 11572484.
↑ Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka TB, Hennet T, et al. (December 2002). "Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen". The Journal of Biological Chemistry. 278 (1): 573–584. doi:10.1074/jbc.M203094200. PMID 12407114.
1 2 "Entrez Gene: GALNT13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)".

Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, et al. (May 2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nature Biotechnology. 19 (5): 440–445. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000144278 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060988 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Nagase_2001-5] Nagase T, Kikuno R, Ohara O (September 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Research. 8 (4): 179–187. doi:10.1093/dnares/8.4.179. PMID 11572484.

[Zhang_2002-6] Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka TB, Hennet T, et al. (December 2002). "Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen". The Journal of Biological Chemistry. 278 (1): 573–584. doi:10.1074/jbc.M203094200. PMID 12407114.

[entrez-7] 1 2 "Entrez Gene: GALNT13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)".

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// Workers AI · dad joke modeWhat did GALNT13 say? "I'm a glyco enzyme, it's a gal thing.

References

Further reading