// Workers AI · dad joke modeWhat did GABRR3 say to its date? You're a gene-ius match.

GABRR3
Identifiers
Aliases	GABRR3, gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene), gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene), gamma-aminobutyric acid type A receptor subunit rho3
External IDs	MGI: 3588203; HomoloGene: 26716; GeneCards: GABRR3; OMA:GABRR3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q11.2 Start 97,985,102 bp End 98,035,315 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C1.3 Start 59,227,695 bp End 59,284,867 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad islet of Langerhans liver right lobe of liver spleen nucleus accumbens Top expressed in primary oocyte secondary oocyte neural layer of retina zygote embryo vasculature vasculature of organ spinal cord temporal lobe amygdala More reference expression data BioGPS n/a
Gene ontology Molecular function chloride channel activity GABA-A receptor activity extracellular ligand-gated ion channel activity ion channel activity transmembrane signaling receptor activity protein domain specific binding Cellular component membrane integral component of membrane cell junction GABA-A receptor complex plasma membrane postsynaptic membrane synapse chloride channel complex cellular component integral component of plasma membrane neuron projection Biological process gamma-aminobutyric acid signaling pathway chloride transport chloride transmembrane transport ion transport chemical synaptic transmission ion transmembrane transport signal transduction regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200959 328699 Ensembl ENSG00000183185 ENSMUSG00000074991 UniProt A8MPY1 B2RXA8 RefSeq (mRNA) NM_001105580 NM_001081190 RefSeq (protein) NP_001099050 NP_001074659 Location (UCSC) Chr 3: 97.99 – 98.04 Mb Chr 16: 59.23 – 59.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Gamma-aminobutyric acid receptor subunit rho-3 is a protein that in humans is encoded by the GABRR3 gene. The protein encoded by this gene is a subunit of the GABA_A-ρ receptor.

Further reading

• Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–6135. doi:10.1074/jbc.M205162200. PMID 12431995.
• Craddock N, Jones L, Jones IR, et al. (2010). "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype". Mol. Psychiatry. 15 (2): 146–153. doi:10.1038/mp.2008.66. PMC 3967096. PMID 19078961.
• Alakuijala A, Palgi M, Wegelius K, et al. (2005). "GABA receptor rho subunit expression in the developing rat brain". Brain Res. Dev. Brain Res. 154 (1): 15–23. doi:10.1016/j.devbrainres.2004.09.010. PMID 15617751.
• Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta. 1447 (2–3): 307–312. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–816. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
• Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–1198. Bibcode:2006Natur.440.1194M. doi:10.1038/nature04728. PMID 16641997.

External links

• GABRR3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)