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Free fraction

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From Wikipedia, the free encyclopedia

The free fraction is a parameter in pharmacokinetics and receptor-ligand kinetics. One speaks of two different free fractions:

  • Plasma free fraction, previously referred to as ƒ1,[1] is now referred to as ƒP according to consensus nomenclature.[2]
  • Tissue free fraction (ƒND), previously referred to as ƒ2[1]

The plasma free fraction is the fraction of the ligand at equilibrium in blood plasma that is not bound to plasma proteins.

See also

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References

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  1. 1 2 Roger N. Gunn; Steve R. Gunn; Federico E. Turkheimer; Vincent J. Cunningham (2002). "Positron Emission Tomography Compartmental Models: A Basis Pursuit Strategy for Kinetic Modeling". J. Cereb. Blood Metab. 22 (4): 1425–1439. doi:10.1097/00004647-200212000-00003. PMID 12468888.Table
  2. ↑ Innis, R.B.; Cunningham, VJ; Delforge, J; Fujita, M; Gjedde, A; Gunn, RN; Holden, J; Houle, S; et al. (2007). "Consensus nomenclature for in vivo imaging of reversibly binding radioligands". J Cereb Blood Flow Metab. 27 (9): 1533–1539. doi:10.1038/sj.jcbfm.9600493. PMID 17519979.

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