Flavone synthase

Flavone synthase
Identifiers
EC no.	1.14.11.22
CAS no.	138263-98-6
Databases
BRENDA	enzyme data
ExPASy	NiceZyme view
KEGG	enzyme entry
MetaCyc	metabolic pathway
Rhea	reactions
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a flavone synthase (EC 1.14.11.22) is an enzyme that catalyzes the chemical reaction

a flavanone + 2-oxoglutarate + O₂ $\rightleftharpoons$ a flavone + succinate + CO₂ + H₂O

The 3 substrates of this enzyme are flavanone, 2-oxoglutarate, and O₂, whereas its 4 products are flavone, succinate, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating). This enzyme participates in flavonoid biosynthesis and isoflavonoid biosynthesis.

References

• Martens S, Forkmann G, Matern U, Lukacin R (2001). "Cloning of parsley flavone synthase I". Phytochemistry. 58 (1): 43–6. Bibcode:2001PChem..58...43M. doi:10.1016/S0031-9422(01)00191-1. PMID 11524111.
• G, Martens S; Matern, U; Junghanns, KT; Heskamp, ML; Britsch, L; Forkmann, G; Martens, S (2001). "Purification and antigenicity of flavone synthase I from irradiated parsley cells". Arch. Biochem. Biophys. 393 (1): 177–83. doi:10.1006/abbi.2001.2491. PMID 11516175.
• Martens S, Forkmann G, Britsch L, Wellmann F, Matern U, Lukacin R (2003). "Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley". FEBS Lett. 544 (1–3): 93–8. doi:10.1016/S0014-5793(03)00479-4. PMID 12782296.